乳腺浸润性微乳头状癌病理分子分型特点及预后分析

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1、浙江大学硕士学位论文英文摘要ThemolecularsubtypesandprognosisinInvasiveMicropapillaryCarcinomaoftheBreastZhcjiangUniversitySchoolofMedicineOncologyPostgraduateHuYapingAdvisorWangLinboAbstractPurpose：Thisstudyaimstocomparethedifferencesofthemolecularsubtypesandprognosisoftheinvasivemicrop

2、apillarycarcinomaofthebreastandtheinfiltratingduetalcarcinomaMethods：Thestudyisbasedon815womenwithhistologicalverifiedbreastCanCerdiagnosedbetween2004and2011atSirRunShawHospital，including14patientswithIMPC．A11women7Schartswerereviewed．AIlrecurrencesanddeathswereregistered．

3、Comparedtheageandmellstrual，operationmeans，chemotherapytime，molecularsubtypes，TMNandprognosis．AnddocumentspublishedfromJanuary1999toMarch2013wereretrievedthroughWeipuandPubmedandthekeywordswere“InvasiveMicropapillaryCarcinoma、breastcancer'’．AndaveragingtheER,PR，Her-2andlym

4、phaticmetastasisResults：IMPCexpressedstrongerpositiveforHer-2andERcomparedtOIDC(p=O．049；p=0．000))．ThemainlymolecularsubtypesoflMPCisLuminalsubtype护0．098)．IMPChasalaterstageofTheTNMstagingsystem(TN：p=0．037)．Thereis110significantcorrelationofOverallSurvivalbetweenIMPCandIDC(

5、p20．997)．25ofthecasestudieswereselectedforthisanalysis，including985IMPCs．TheaverageERpositiveis64．9％，PRpositiveis50．2％，HER-2positiveis56．8％，lymphaticIV浙江大学硕士学位论文英文摘要Conclusions：1MPChasahighriskoflymphaticmetastasis，recurrencerisk,butthereisnosignificantcorrelationofOverall

6、Survival．-TheintemetresearchindicatesIMPChasahigherlymphaticmetastasisandHer-2over-expression．Keywords：InvasiveMicropapillaryCarcinomaoftheBreast；invasiveductalcarcmoma；immunohistochemistry；molecularsubtypes；OverallSurvival；Disease．FreeSurvivalV目录致谢⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯

7、⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．I中文摘要⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．．Ⅱ英文摘要⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯Ⅳ目录正文l引言⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯l2材料与方法⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯33结果⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯64讨论⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．135结论⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯

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