慢性乙肝治疗初始治疗方案的选择

《慢性乙肝治疗初始治疗方案的选择》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、ChoosingFirst-LineTherapyinChronicHepatitisBThisprogramissupportedbyanunrestrictededucationalgrantfromAboutTheseSlidesUsersareencouragedtoincludetheseslidesintheirownpresentations,butweaskthatcontentandattributionnotbechanged.Usersareaskedtohonorthisintent.Theseslide

2、smaynotbepublishedorpostedonlineorusedforanyothercommercialpurposewithoutwrittenpermissionfromClinicalCareOptions.WearegratefultoEmmetB.Keeffe,MD,MACP,withtheStanfordUniversityMedicalCenterinPaloAlto,California,foraidinginthecontentdevelopmentoftheseslides.Participan

3、tshaveanimpliedresponsibilitytousethenewlyacquiredinformationtoenhancepatientoutcomesandtheirownprofessionaldevelopment.Theinformationpresentedinthisactivityisnotmeanttoserveasaguidelineforpatientmanagement.Anyprocedures,medications,orothercoursesofdiagnosisortreatme

4、ntdiscussedorsuggestedinthisactivityshouldnotbeusedbyclinicianswithoutevaluationoftheirpatient’sconditionsandpossiblecontraindicationsondangersinuse,reviewofanyapplicablemanufacturer’sproductinformation,andcomparisonwithrecommendationsofotherauthorities.OutlineIntrod

5、uction:ConsiderationsforSelectingInitialHBVTherapyCaseVignette:First-lineTreatmentinanHBeAg-PositivePatientReviewofkeyfactorsindetermininginitialtherapyinHBeAg-positivepatientsCaseVignette:First-lineTreatmentinanHBeAg-NegativePatientReviewofkeyfactorsindeterminingini

6、tialtherapyinHBeAg-negativepatientsCaseVignette:First-lineTreatmentinaCirrhoticPatientWithHepatitisBReviewofkeyfactorsindetermininginitialtherapyincirrhoticsConsiderationsforSelectingFirst-LineTherapyinHepatitisBGoalsoftherapyCandidacyfortherapyBaselinepatientfactors

7、HBeAgpositivevsHBeAgnegativeHBVgenotypeHBVDNAlevelALTlevelPresenceorabsenceofcirrhosisSignificantpatientcomorbidities(ie,depression,kidneydisease)TreatmentfactorsExpecteddurationoftherapyEfficacyofavailabletherapiesResistanceprofilesofavailabletherapiesCase1:Choosing

8、First-LineTherapyinanHBeAg-PositivePatientHistory36-year-oldmalewithHBVinfectiondiagnosed6yearsagoattimeofblooddonationCurrentlyas