丹参酮对大鼠放射性肝损伤的治疗保护作用的试验分析

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1、英文摘要methodtotestTGF—p1inthreegroups．Observethedifferenceoflivertissuesampleandliverpathologyslice．Results：1Therats’grossliverinnormalcontrolgroupwashenna，withsmoothycapsule，sharpmarginandmediumtexture．Theliverinmodelgroupwasintumesce，edgecomingtoblunt，wineorlessredness，pa

2、wnsoft，fluctuatesensitive．Theliverinexperimentalgroupwasswelling，wine．Therearegreatdifferencebetweentheliverinmodelgroupandnormalcontrolgrouponvolume，colorandtexture，thedifferencebetweentheliverinexperimentalgroupandnormalcontrolgroupisrelativelysmaller．2Weappliedspss10．0

3、softwaretoanalyzethedata．LSDandDunnett’SwereperformedtocomparethevalueofAI』、TGF一131andMDAofthreegroupsandtherewassignificantstatisticdifference(p

4、thehepaticinjurymodel．Thevalueof札Tinexperimentalgroupwaslowerthanthatinmodelgroup，whichshowedthattanshinoneIIAperitonealinjectioncanremarkablyreducethehepaticinjurycausedbyradiation．ThevalueofALTinexperimentalgroupwashigherthanthatinnormalcontrolgroup，whichillustratedthat

5、themedicinecanreducethedegreeofhepaticinjurybutitcannotcompletelyimprovethehepaticinjury．2．2MDAistheendproductoflipidperoxidationdamage．’l'hevalueofMDAinmodelgroupwashigherthanthatinnormalcontrolgroup，whichindicatedthatradiationcancause英文摘要peroxidationdamageandthedamagewa

6、smoreseriousinmodelgroup．7l'hevalueofMDAinexperimentalgroupwaslowerthanthatinmodelgroup，whichillustratedthattanshinoneIIAperitonealinjectioncanreducethedegreeoflivertissue’peroxidationdamagecausedbyradiation．ThevalueofMDAinexperimentalgroupwashigherthanthatinnormalcontrol

7、group，whichillustratedthatthemedicinecanreducethedegreeofperoxidationdamagebutitcallnotcompletelyimprovethehepaticinjury．2．3Inliver，TGF一131wasmainlysynthesizedbynonparenchymalcell，suchasKupffercell、hepaticstellatecell、myofibroblastandSOon．Itwascloselyrelatedwiththehepatic

8、injury,andthedegreeeofhepaticinjuryhadpositivecorrelationwithTGF一131．Inourexperiment，TGF一131inmo