大鼠急性脑缺血后cd42bcd252b调节性t细胞、tgf-β1的表达与其相关性分析

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1、硕士学位论文CD25+调节性T细胞的表达存在着正相关，提示TGF．B1可能是诱导急性脑缺血后CD4+CD25+调节性T细胞表达的调节通路。关键词脑缺血；CD4+CD25+调节性T细胞；Foxp3：TGF—B1；调节通路V硕士擘位论文一‘dcorrelationofCD4十CDExoressionan25十Z5。regulatoryTcellsandTGF-—plafteracutecerebralischemiaofRatliSCeABSTRACTIsehemicstrokeisageneralizedcerebralinfarction，referstoasu

2、ddenhappenmedalbloodperfusionreduceorbloodflowcompletelystopoflocalbrain，stopblood、oxygen、sugarsupplying，makingthelocalbraintissuedisintegrationdamage．Ischemicstroketobecomeoneofthemajorcausesofdeathanddisabilityamongadultsintheworldtoday,theirhighmortalityrates、highdisabilityratesac

3、cessmoreandmorepeople’Sattention．Inthelotsofmeasuresofthetreatmentforcerebralinfarction，thrombolysisistheonlyexactandeffectivesolutionwhichhasbeenrecognized，butduetotheshortertreatmenttimewindowandhighbleedingrisk，limititsapplicationinclinical．Alotofresearcheshavereportedthatthereisa

4、extradamageonbrainafteracutecerebralischemiaforalongtime，becausethereisanobviousinflammatoryresponseareaaroundthecerebralischemictissue，thelevelofinflammatoryresponsesarecloselylinkedtotheneuralfunctionafterischemiadamage．Furthermore，Acalovschithinksthatinflammatoryresponsesonischemi

5、cbrainmakemoreseriousinjurythantheischemiaitselfintheacutestageofcerebralischemia．Anotherviewpointedoutthat，duetoblood-brainbarrierdamageandtissuedamageresultinginbrainAntigenepitopeisexposedtotheimmunesystemaRerischemicstroke，whichcau沱autoimmuneinjury．Studieshaveshowntllatadvancedin

6、duceimmunetolerancetoantigensphingomyelinalkaliprotein(MBP)lABSTRACTofnervoussystemcansuppressautoimmuneresponsesofthenervoussystem,whichimprovestrokeoutcome．Usuallyconsideredthat”pro-inflammatoryresponse”haveanervedamageeffectand”anti-inflammatoryreactions”hasaneuroprotectiveeffecti

7、nthecentralnervoussystem．Suppressing‘‘inflammatoryimmuneresponse’’or‘‘autoimmuneresponse”afterfocalcerebralischemiamaybecomeaimportanttargetforthetreatmentoffocalcerebralischemicinjury．However,themechanismsofinflammatoryresponsesafterfocalcerebralischemiahavenotcompletelyclarified，es

8、peciallyther