内质网应激介导自吞噬对脂多糖诱导hl-1心肌细胞损伤保护机制的研究

《内质网应激介导自吞噬对脂多糖诱导hl-1心肌细胞损伤保护机制的研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、分类号学号D200978280学校代码10487密级博士学位论文内质网应激介导自吞噬对脂多糖诱导HL-1心肌细胞损伤保护机制的研究学位申请人：徐建军学科专业：麻醉学指导教师：姚尚龙教授答辩日期：二〇一二年五月ADissertationSubmittedtoHuazhongUniversityofScienceandTechnologyinConformitywiththeRequirementsfortheDegreeofDoctorofScienceMechanismofprotectionofautop

2、hagytriggeredbyERSagainstLPS-inducedinjuryinHL-1cardiomyocytesCandidate:XuJianjunSupervisor:Prof.YaoShanglongMDPHDMajor:AnesthesiologyHuazhongUniversityofScience&TechnologyWuhan430074,P.R.ChinaMay,2012独创性声明本人声明，这里呈交的学位论文是我个人在导师的指导下进行的研究工作及取得的研究成果。除文中已标明引用的

3、内容外，本论文不包含任何其他个人或集体已经发表或撰写过的研究成果。对本文的研究做出贡献的个人和集体，均已在文中以明确方式标明。本人完全意识到本声明的法律效用，一切后果由本人承担。学位论文作者签名：日期：年月日学位论文版权使用授权书本学位论文作者完全了解学校有关保留、使用学位论文的规定，即：学校有权保留并向国家有关部门或机构送交论文的复印件和电子版，允许论文被查阅和借阅。本人授权华中科技大学可以将本学位论文的全部或部分内容编入有关数据库进行检索，可以采用影印、缩印或扫描等复制手段保存和汇编本学位论文。保密□，

4、在______年解密后适用本授权书。本论文属于不保密□。（请在以上方框内打“√”）学位论文作者签名：指导教师签名：日期：年月日日期：年月日目录中英文缩略词··································································································1中文摘要············································································

5、······························3Abstract···········································································································6第一部分自吞噬对脂多糖诱导HL-1心肌细胞凋亡的保护作用············101.前言·······························································

6、······································102.材料和方法···························································································113.实验方法·······························································································134.统计学方法······

7、·····················································································205.结果·····································································································206.讨论··························································

8、···········································247.参考文献·······························································································27第二部分脂多糖诱导自吞噬对HL-1心肌细胞线粒体功能影响的研究·····························