组织工程肌腱支架增强体的结构与性能-研究

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1、东华大学硕士论文摘要关键词：组织工程肌腱，支架增强体，结构，降解性能，口径，孔隙率东华大学硕士论文ABSTRACTRESEARCHON唧STRUCTUREANDPROPERTYOFTHESCAFFOLDFORTENDONTISSUEENGINEERINGABSTRACTTendoninjuryisverycommoninthephysicallyactivepopulation．Thetissueengineeringtechniqueprovidesanidealmethodandkeepsthepromisefortendonrepair．ThetendonCanavoidtheresou

2、rcerestrictions，immunereactions，andimmuseresponseproblem．Besidestheneworganizationhasviabilityandfunction，andCanreachtothenormaltendonshape．Theperformanceofscaffoldincludesbiocompatibility,mechanicalpropeny，structuralstabilityandtheporositysize．Presentstudiesoftissueengineeringscaffoldsalsohavegoodb

3、iocompatibility．Howeverthesescaffoldscannotsatisfytherequirementsatthesametime：stablestructure，largerporosity,andgoodmechanicalproperties．Thispaperselectpologiycolicacid(PGA)andpolylacticacid(PLA)multifilament，theybothhavegoodbiocompatibility．UtilizingPGAandPLAmultifilamenttobraidcombinedyams，andthe

4、plainstitchandtricotstitcharemanufacturedthroughweftandwarpknittingtechnologywhiletherhombicandrectangularnettystructurescaffoldreinforcementsarehand-knitted．Wecomparedtheextensibility，porosity,poresize，andmechanicalpropertiesofthefourkindsofscaffoldreinforcements．Thestudieshaveshownthatrhombicnetty

5、structurescaffoldreinforcementhasstablestructureandsmallextension，butitsmechanicalpropertyislow．Theplainstitchnettystructurescaffoldreinforcementhasthesmallestporosityandporesize，butitsmechanicalpropertyisthebest．Thispaperstudiedthebasicproperties，performanceduringdegradationinvitroofPGAandPLAmultif

6、ilament，besidesresearchedtheperformanceofbraidedyamsandtheirscaffoldswithdifferentPGA／PLAduringdegradationprocess．TheresultsshowedthatthePGAmultifilamentdegradedfasterthanPLAmultifilament，PGA'sstrengthCan’tgettwoweekslater,anditlostalmostallthemassafter5-weekdegradation．ButtheperformanceofPLAmultifi

7、lamenthadlittlechange．AsthePGAincreasedamongPGA／PLAbraidedyams，thedegradationspeedofbraidedyamsandscaffoldsincreased．Thefinenessofbraidedyamshadnoeffecttobraidedyams’degradation，buthadalittleeffecttos