大鼠大脑中动脉栓塞模型早期脑血流变化的分析

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1、上海交通大学硕士学位论文MCAOstrokemodelusingourself-developedreal-timeLSCIsystem.CBFimagesofadultmaleSpragueDawleyrats(N=12)wererecordedbeforesurgeryasbaseline,duringfirst1.5hoursaftersurgery,andat24hoursafterstroke.WecomparedtheCBFchangesafterstrokesurgeryandgottheresultsasbelow:(1)Intheipsilateral

2、hemisphere,CBFoftheveinandthearterydecreasedto45%and30%ofbaseline,thenrecovered15%and5%respectively,andwas42%and32%at24hoursafterthesurgery,whileCBFoftheveinkeptabovebaselineafterocclusioninthecontralateralhemisphere.(2)Diametersoftheveinsinipsilateralandcontralateralhemispheresvariedaft

3、erthestrokesurgery.Thediameterofipsilateralveinreducedatfirstandthenincreasedgradually,andremainedbelowbaselineatthe24hoursaftersurgery,whilethediameterofcontralateralveinremainedabovebaselinepostischemia.(3)Therewasahighcorrelationbetweenthebraininfarctvolume24hoursafterischemiaandtheCB

4、Freductionduringthefirst30minutesafterMCAocclusion.When50%ofCBFreductionwassetasthreshold,thecorrelationcoefficientbetweenitscorrespondingcortexareaandtheinfarct2volumereachedthemaximumatthefirstminuteafterocclusion（R=0.540,IV万方数据上海交通大学硕士学位论文p<0.05）.When25%wassetasthreshold,thecorrelatio

5、ncoefficient2achievedthemaximumvalueatthe30thminuteafterocclusion（R=0.571，p<0.05）.OurobservationsprovidevaluableinformationinunderstandingtheCBFspatio-temporalchangesduringearlystageofratMCAOmodel.ThecorrelationbetweenCBFvariationandbraininfarctvolumeshowsthatCBFreductionimmediatelyafter

6、thefilamentocclusioncanbeusedasapredictorofbraininjurysize.Moreover,LSCImayhelpwiththeguidanceofsurgeryproceduresoastoimprovetheconsistencyofratMCAOstrokemodels.KEYWORDS:middlecerebralarteryocclusion(MCAO),stroke,cerebralbloodflow(CBF),laserspecklecontrastimaging(LSCI)V万方数据上海交通大学硕士学位论文目录

7、摘要.............................................................................................................................IABSTRACT...............................................................................................................III第一章绪论.................