脱细胞猪心包膜对兔股骨骨缺损引导骨再生影响的实验分析-(6131)

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1、2.4组织学观察·······················································································12第3章讨论···························································································163.1猪心包脱细胞处理··············································································163.2APP的交联处理

2、·················································································163.3APP的降解与转归··············································································173.4APP的引导骨再生作用········································································17第4章结论·····························

3、······························································19参考文献································································································20综述······································································································23综述参考文献···················

4、·······································································29攻读学位期间的研究成果··········································································33参加国内会议··························································································34致谢·····································

5、·································································35学位论文独创性声明················································································36万方数据引言引言在牙种植手术中，经常会因为种植术区骨量的不足从而限制了种植体的植入。[1]近年来，引导性骨再生（Guideboneregeneration,GBR）技术的出现很大程度的弥补了这一缺陷，提高了种植手术的成功率。其主要原理是利用引导骨再生膜的物理屏障作用，隔绝骨缺损

6、区与周围软组织，为新骨的形成创造一个良好的环境和空间。理想的GBR膜材料应该具有良好的生物相容性，同时还具有适宜的降解吸收时间，能促进细胞和组织的生长，以保证再生的组织能够具有原有组织的活性和功能。目前，引导性骨再生材料主要可以分为不可吸收和可吸收膜两大类。不可吸收膜主要有钛膜、聚四氟乙烯膜，其中最具代表性的是扩展型聚四氟乙烯膜（Expanded[2,3]Polytetrafluoroethylene,e-PTFE）。可吸收膜主要有Bio-gide膜、胶原膜、聚乳酸膜，其中最具代表性的是胶原膜。不可吸收膜质地坚硬有利于塑形，但需二次手术取出，且出现术后并发症的几率较大。相比之下，胶原膜可

7、以解决这些问题，其组织相容性好，抗原性小，越来越受到学者们的青睐，胶原膜制备已成为近年来[4]引导组织再生膜的研究热点之一。周先略等将冷冻的异体硬脑膜作为引导性骨再生材料用于骨量不足的牙种植手术，并取得了不错的临床效果。猪心包胶原衍生材料作为一种新型医用材料被应用于临床已经有很长的历史。[5]庄永珍等将猪心包制成的人工心脏瓣膜置于一例患者体内，该瓣膜的使用寿命达18年。猪的心包膜厚度介于人心包膜和牛心包膜之间，它由3层结构组成：近心