hmgb1与其受体rage在宫内感染后早产儿脑损伤中的作用与临床意义

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1、万方数据江苏大学硕士学位论文RAGE表达均明显增强，提示HMGBl／RAGE可能参与-]'BIPI的发生发展，且其变化程度与脑损伤的严重程度具有一定的相关性。2．脑损伤早产儿脐血中sRAGE水平明显下降，其水平的变化程度与病变程度呈负性相关，提示sRAGE对早产儿脑可能具有保护性作用。3．宫内感染与BIPI密切相关，且炎症程度越重，脑损伤程度越重。4、检测HMGBl、RAGE及sRAGE可为临床早期诊断BIPI提供预警。关键词：早产儿；脑损伤；宫内感染；HMGBl；RAGE；sRAGEIII万方数据ABSTRACT【objective】Theobjectiveofthisstudywa

2、stoexploretheroleofhigh-mobllity黟oupboxl(HMGB1)andreceptorforadvancedglycationendproducts(RAGE)intheoccurrenceanddevelopmentofbraininjuryinprematureinfants(BIPI)afterintr绷‘eriIleinfection(IUl),throu卧analyzingthechangeofthese啪proteinsinumbilicalcordbloodandplace呲MeanWhiletherelationshipbe帆enplace

3、n协linflammationandBIPIhavebeenanalyzed‘【Methods】Onehundredandeightcasesofprematureinfantswith30．32眦eksge贼1删a2ethat、Ⅳerebomfrom2012Septemberto2014JanuaryinneonatologYoftheAfllllatedHosDitalofJiangsuuniversitywereselected．Allselectedinfantsreceivedomphalotomyimmediatelyafterdelivery，meanwhiledraw3

4、mlumbilicalcordbloodandcentrifuge·AndtheconcentrationofHMGB1andSolubleRAGE(sRAGE)inumbilicalcordbloodwe佗measuredbyenzyme．1inkedimmunosorbentassay(ELISA)·AllthePlacentalweresubml仳dforpathologicevaluationandimmunohistochemicalanalysis·ThepathologicalchangesmtheplacentaweredetectedbyHEstainingmetho

5、dandthenumberofneunDphilinfn似10nwerecountedsimultaneously．ExpressionsofHMGB1andRAGEproteinsinplacentalwereassessedbyimmunohistochemicalanalysis．ThediagnosisandgradingofBIPI眦佗conformedaccordingtobrainultrasoundorMRI．Andthese108infantswe㈣nallYdiVidedint03groups：controlgroup(nobraininjuryinfants)，m

6、ildbraininjurygroupandseVerebralninjurygroup．ThediagnosticcriteriaofIUlwasthatplacentalhistopathol091c既帅1n砒10nhadchorioamnionitis．Andaccordingtoit，thepreterminfantswithbraininjurywerefurtherdiVidedintoBIPlwithIUIgroup，BIPlwithoutIUIgroup，andselectinfantswithoutbothRIPIand11II1．1．Clinicalcharacte

7、risticsofthestudypopulation：atotalof108infantswereselected，6，casesinthecontroI伊oup，33casesinmildbraininjurygrouPand8inseveregroup·1hegestationalage,birthweight，gender，cesarean，hormoneandpulmonary811订anantuse，锄d二echanicaIvent