小蔓长春花提取物治疗大鼠脑梗死的实验分析

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1、中文摘要SOD，GSH．PX的活力，清除毒性自由基，从而降低了MDA的含量。4．VMLE可改善MCAO大鼠的学习记忆能力。以上结果均提示VMLE对实验性脑缺血具有一定预防和治疗作用，这为进一步扩大其开发研究提供了实验依据。5．VMLE高剂量组(109／kg／d)MCAO大鼠在实验过程中出现腹泻，自洁作用降低，说明VMLE含有一定的毒性成分，有待进一步提纯。关键词：小蔓长春花提取物；脑梗死；缺血再灌注；大鼠；脑梗死模型；学习记忆；脑梗死范围英文摘要ExperimentalResearchonTherapeuticEffectsofVincaMinorLinnExtracton

2、FocusCerebralIschemia--ReperfusionInjuryinRatsABSTRACTobjective：Vincaminorlimaisakindofperennialclimingshuboftheapocynaceae，itgrowsintemperateregioninEurope．ThereiSnotthekindofnaturalresourceofplantinourcountryinthepast．Becauselivesandtenderstemsoftheplantcontainamainalkloids-Vincamine，itc

3、animproveoxygensupplyinginthebrainandexpendcerebralvascular．Itissignificiantlyeffectonischemiccerebralvascular．Vincaminecontainedinvincaminor1inncantreatthevasculardiseaseofheartandbraineffectlyandwasappliedinclinicaltreatmentwidelyandacquairesobvioustherapeuticeffect．ButwhetherVincaminorl

4、innextract(VMLE)hasthesametherapeuticeffect，shouldbefurtherstudied．TheresearchwillinvestigatetheprotectiveeffectofVMLEbvalcoholextractionontheexperimentalCerebralIschemiainRats．confirmpreventionandcurefunctionoftheextract，andobserveitssafetyandside—effects，provideexperimentalattestationsfo

5、rfuthurdevelopmentandutilization．Methods：1．Extractionofvincaminorlinn：Vincaminorlinnwassheared、immersedwithethanol、heatedandrefluxed、filtrated、condonsed，andVMLEwasobtained．ThecontentofVincaminewasdeterminedbyhighperformanceliquid．2．Acute6英文摘要toxicologicalexperimentoftheextract：Toadministra

6、teKunmingmicebygastricperfusionofVMLEandinvestigatechangesoftheirsignsanddeathstatusfor14days，thenevaluatethesafetyoftheextract．3．AdoptingZea—LongatraditionalmethodtomakeMCA0model．whichiSthemiddlecerebralarteryocclusion(MCAO)modelinducedwithsilksuturetoobstructmiddlecerebralarteryofrats．4．

7、Groupingandadministration：(1)SDmalerats(2509-3009)weredividedrandomlyintoexperimentalgroupandcontrolgroupaccordingtotheirbodyweight．Theexperimentalgroupwasdividedrandomlyintohighdose(109／kg／d)andlowdose(59／kg／d)groupofVMLE．Thecontrolgroupwasdividedrandomlyinto