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ID:33004552
大小:1.25 MB
页数:30页
时间:2019-02-19
《早期子宫内膜癌93例临床分析》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、早期子宫内膜癌93例l临床分析硕士生姓名:指导教师:指导小组:专业名称:孙希文石红教授高娜妇产科学摘要的:过分析93例早期子宫内膜癌患者的临床资料,研究分段诊刮在早期子宫内膜癌诊断中的临床价值,并探讨不同病理类型、病理分级、肌层浸润深度、腹水细胞学、CAl25水平、病灶大小与盆腔淋巴结转移的关系,不同术式之间的比较及它们的临床意义。方法:收集大连医科大学附属第一医院妇科2002年1月~2005年3月收治的93例术前或术后诊断为I、II期子宫内膜癌患者的临床资料,对其进行回顾性分析。结果:1.分段诊刮诊断子宫
2、内膜癌灵敏度达91.3%,特异度为96.74%,特殊病理类型癌(除内膜样腺癌以外的病理类型)的诊断符合率(27.27%)低于子宫内膜样腺癌的符合率(93.94%)。P=0.000;高分化癌的诊断符合率(27.78%)低于中低分化癌的符合率(80%),P=O.0l6。2.特殊病理类型、肌层浸润深度之l/2、病理分级>G2、血清CAl25>75/45U/ml(绝经前/绝经后)、内膜病灶最大径线>4cm的I期子宫内膜癌患者分别较子宫内膜样腺癌、肌层浸润<1/2、病理分级3、内膜病灶最大径线<4cm患者盆腔淋巴结转移机率高。结论:1.分段诊刮对子宫内膜癌诊断具有重要意义,但在特殊病理类型、高分化癌和分期诊断上存在局限性,符合率低。提示术中先行切除子宫行冰冻病理检查进一步明确有无高危因素对决定术式(盆腔淋巴结切除)很有必要。2.术前分段诊刮存在一定的漏诊率,对于诊刮病理为不典型增生甚2出血形式及除。血清CAl25盆腔淋巴结,特别是存内膜癌患者,可能对Istage93casesofearly·stageendometrialcarcinoma,andexploredthevalue4、offraetionalcurettageinthisdisease,meanwhile,itexploredtherelationshipsbetweendifferentpathologictypes,pathologicdifferentiation,depthofmyometrialinvasion,peritonealcytology,levelsofserumCA125,sizeofneoplasmas,andmetastasisofthelymphnodes,italsocompareddif5、ferentsurgerysandexploredtheirclinicalsignificance.Method:Theclinicaldatasof93patientsofendometrialcarcinomawerecollectedandretrospectiVelyanalyzed.AllthesepatientswerepreoperativelyorpostoperatiVelydiagnosedasstage-Iorstage—IIendometrialcarcinomaandadmitt6、edtOthedepartmentofGynecologyoffirstaffiliatedhospitalofDalianMedicalUniversityfromJan2000toMarch2005.Results:1.Thesensibilityandspecificityoffractionalcurettagewas91.3%and96.74%,respectively.Thecoincidencerateofdiagnosisforspecialpathologictypes(notendome7、trioidadenocarcinoma)was27.27%,lowerthanthatofendometrioidadenocarcinoma(93.94%),P=0.000;andthecoincidencerateofdiagnosisforwelldifferentiatedcancerwas(27.78%),lowerthanmoderateorpoordifferentiatedcancer(80%),P=0.016.2.Thelymphnodemetastasisofendometrialca8、rcinomaofstage—1wasrelatedto—specialpathologictypes,myometrialinvasion>1/2,pathologicdifferentiationworsethanG2,serumCA125>75/45U/mI(premenopause/postmenopause),thebiggestdiameterofendometrialneoplasma>4cm.Th
3、内膜病灶最大径线<4cm患者盆腔淋巴结转移机率高。结论:1.分段诊刮对子宫内膜癌诊断具有重要意义,但在特殊病理类型、高分化癌和分期诊断上存在局限性,符合率低。提示术中先行切除子宫行冰冻病理检查进一步明确有无高危因素对决定术式(盆腔淋巴结切除)很有必要。2.术前分段诊刮存在一定的漏诊率,对于诊刮病理为不典型增生甚2出血形式及除。血清CAl25盆腔淋巴结,特别是存内膜癌患者,可能对Istage93casesofearly·stageendometrialcarcinoma,andexploredthevalue
4、offraetionalcurettageinthisdisease,meanwhile,itexploredtherelationshipsbetweendifferentpathologictypes,pathologicdifferentiation,depthofmyometrialinvasion,peritonealcytology,levelsofserumCA125,sizeofneoplasmas,andmetastasisofthelymphnodes,italsocompareddif
5、ferentsurgerysandexploredtheirclinicalsignificance.Method:Theclinicaldatasof93patientsofendometrialcarcinomawerecollectedandretrospectiVelyanalyzed.AllthesepatientswerepreoperativelyorpostoperatiVelydiagnosedasstage-Iorstage—IIendometrialcarcinomaandadmitt
6、edtOthedepartmentofGynecologyoffirstaffiliatedhospitalofDalianMedicalUniversityfromJan2000toMarch2005.Results:1.Thesensibilityandspecificityoffractionalcurettagewas91.3%and96.74%,respectively.Thecoincidencerateofdiagnosisforspecialpathologictypes(notendome
7、trioidadenocarcinoma)was27.27%,lowerthanthatofendometrioidadenocarcinoma(93.94%),P=0.000;andthecoincidencerateofdiagnosisforwelldifferentiatedcancerwas(27.78%),lowerthanmoderateorpoordifferentiatedcancer(80%),P=0.016.2.Thelymphnodemetastasisofendometrialca
8、rcinomaofstage—1wasrelatedto—specialpathologictypes,myometrialinvasion>1/2,pathologicdifferentiationworsethanG2,serumCA125>75/45U/mI(premenopause/postmenopause),thebiggestdiameterofendometrialneoplasma>4cm.Th
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