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1、干预前后清洁切口手术围术期抗菌药物使用和医院感染情况对照探究［摘要］目的评价专项整治对规范清洁切口手术围术期抗菌药物使用的作用，进一步促进围术期抗菌药物的合理规范化使用。方法回顾性分析2010年5〜12月甲状腺、乳腺、疝气3种I类切口手术切口患者120例（对照组）和2012年5〜12月开展专项整治后的同类手术及切口的患者125例（干预组）的临床资料，对比分析两组预防性使用抗菌药物情况及其合理性。结果对照组抗菌药物使用率、二联用药率（96.7%、21.5%）均明显高于干预组（20.8%、3.8%）,差异均有统计学意义（均
2、P0.05）。结论开展专项整治后,3种I类切口手术预防用抗菌药的合理性明显改善，应继续深化抗菌药专项整治，促进抗菌药规范使用。［关键词］清洁切口手术；抗菌药物；干预；围术期［中图分类号］R969.3［文献标识码］B［文章编号］1673-7210(2014)04(a)-0146-04Controlstudyofantibacterialuseandhospitalinfectionbeforeandaftertheinterventionofcleanincisionoperationinperioperativeper
3、iodZHANGLilLITong2FENGGanzhu31.ClinicalPharmacyRoom,theSecondAffiliatedHospitalofNanjingMedicalUniversity,JiangsuProvince,Nanjing210011,China；2.CollegeofPharmacy,NanjingMedicalUniversity,JiangsuProvince,Nanjing210029,China；3.DepurtmentofInfections,theSecondAffil
4、iatedHospitalofNanjingMedicalUniversity,JiangsuProvince,Nanjing210011,China[Abstract]ObjectiveToevaluatetheeffectofrectificationinantibacterialuseincleanincisionoperationinperioperativeperiod,andfurtherpromotethereasonablestandardizationofantimicrobialuseinperio
5、perativeperiod・MethodsClinicaldataof120caseswithclassIsurgicalincisionafterabdominalexternalhernia,breastandthyroidoperationfromMaytoDecember2010(controlgroup),and125caseswiththesameoperationandsurgicalincisionaftertherectificationfromMaytoDecember2012(intervent
6、iongroup)wereretrospectiveanalyzed・Theconditionandrationalityofantimicrobialdrugpreventabilityuseoftwogroupswerecompared・ResultsTherateofantibacterialdrugusageandduplexcombinationusageininterventiongroup(96・7%,21.5%)wereobvioushigherthanthoseincontrolgroup(20.8%
7、,3.8%)),thedifferenceswerestatisticallysignificant(allP0.05).ConclusionTherationalityofantimicrobialdrugpreventabilityuseafteroperationofclassIcleanincisionisobviouslyimproveaftertherectification,thespecialantibacterialshouldbecontinuedeepen,topromotethestandard
8、izationuseofantimicrobials・[Keywords]Cleansurgicalincision；Antibacterialdrugs；Intervention；Perioperative随着抗菌药物的广泛应用，临床不合理用药的状况也日渐增多，细菌耐药性不断增强[1],加强抗菌药物的管理势在必行。根据卫生部抗菌
