部分锥型构象固有手性杯[4]冠醚羧酸衍生物的合成、拆分及手性识别研究

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1、分类号学号M201075111学校代码10487密级硕士学位论文部分锥型构象固有手性杯[4]冠醚羧酸衍生物的合成、、拆分及手性识别研究、拆分及手性识别研究学位申请人石姣学科专业药物化学指导教师罗钧答辩日期2012年年年12月月月ADissertationSubmittedinPartialFulfillmentoftheRequirementsfortheDegreeofMasterSynthesis,opticalresolutionandchiralrecognitionresearchofinherentlychira

2、lcalix[4]crowninpartialconeCandidate:ShiJiaoMajor:PharmacochemistrySupervisor:LuoJunHuazhongUniversityofScienceandTechnologyWuhan,Hubei430074,P.R.ChinaDec,2012目录中文摘要....................................................................................................

3、....................1英文摘要........................................................................................................................2正文部分前言.................................................................................................................

4、...............3第一章双丙基醚化的部分锥型构象固有手性杯[4]冠醚羧酸的设计研究.............61.1设计思路...............................................................................................................61.2主要仪器和试剂..........................................................................

5、.........................71.3原料合成...............................................................................................................91.4结果与讨论.........................................................................................................101.4.1

6、合成步骤....................................................................................................101.4.2手性拆分....................................................................................................141.4.3化学拆分过程副产物结构的初步推断...........................

7、..........................161.4.4核磁共振谱图分析....................................................................................181.4.5X-衍射单晶数据分析..................................................................................201.5手性识别研究..............................

8、.......................................................................2611.5.1HNMR滴定............................................................