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ID:32839404
大小:2.37 MB
页数:47页
时间:2019-02-16
《survivin、fas与fasl在宫颈癌介入化疗前后组织中的表达及意义》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、青岛大学硕士学位论文Survivin、Fas与FasL在宫颈癌介入化疗前后组织中的表达及意义姓名:董艳申请学位级别:硕士专业:妇产科学指导教师:王蓁20120610Survivin、Fas与FasL在宫颈癌介入化疗前后组织中的表达及意义中文摘要目的:探讨细胞凋亡相关蛋白Survivin、Fas与FasL在宫颈癌术前行动脉介入化疗前后组织中的表达变化,根据阳性表达及其相关性,并结合宫颈癌的临床病理特征(宫颈癌临床病理分期、组织学类型及淋巴转移等)分析Survivin、Fas、FasL的表达变化与宫颈癌发生、发展的关系及其临床意义。方
2、法:采用PV一6000二步免疫组化的方法,检测56例IB—IIB期的富颈癌介入化疗前、后组织标本、40例正常宫颈组织标本以及30例宫颈上皮内瘤变组织标本中Survivin、Fas、FasL的表达水平,并对比宫颈癌介入化疗前、后组织中三种因子阳性率的表达变化,研究Survivin、Fas、FasL与宫颈癌的临床病理特征关系,并对三种因子之间的相关性进行分析,探讨介入前后Survivin、Fas、FasL的表达变化与临床有效性的关系。结果。介入化疗前宫颈癌组织中Survivin、FasL的阳性表达率分别为85.7%、91.1%,而Fa
3、s的阳性表达率为48.2%;介入化疗后宫颈癌组织中Survivin、FasL的阳性表达率分别为28.5%、46.4%,而Fas的阳性表达率为96.4%,介入化疗前后比较,差别有统计学意义(P4、关,术前动脉介入化疗可能通过抑制Survivin、FasL并促进Fas表达来诱导宫颈癌细胞的凋亡。从而达到抑制肿瘤生长、缩小肿瘤体积、降低临床分期及抑制远处转移的目的。硕士研究生董艳(妇产科学)指导教师王蓁教授【关键词】介入化疗;宫颈癌;Survivin;Fas;FasLExpressionofSurvivin,FasandFasLincervicalcarcinomatissuebeforeandafterthearteriafemoralisinterventionalchemotherapyandclinicalsignif5、icance.AbstractObjeetiveToevaluatedifferentexpressionofSurvivin,FasandFasLincervicalcarcinomacellsbeforeandaftertheartefiafemoralisinterventionalchemotherapyandclinicalsignificance,andtoanalyazetheircorrelationbyexamingtheirpositiveratesinthecervicalcarcinomaandtoinve6、stigatetherelationsofSurvivin,FasandFasLandtheprocessofinvasionandmetastasisofcervicalcarcinomascombiningtheclinicopathologicalfeatures(surgicalpathologicalstage,histologicaltypeandlymphmetastasis).MethodsSamplesfrom40casesofnormalcervix,30casesofcervicalintraepitheli7、alneoplasia(ClN)and56cervicalcancerwitllstageIB-IIB,whichincludedtissuesbeforeandaftertheinterventionalchemotherapy,sampleswereexaminedandmarkedthroughPV·6000immunohistochemicalmethodforSurvivin,FasandFasL.Weexaminedtheircorrelationsandrelmions、Ⅳiththeclinicopathologi8、calstage,histologicalgradeandhistologicaltypeoftheendometrialcarcinomasbyexamingthepositiveratesoftheSurvivin,FasandFasL.Bes
4、关,术前动脉介入化疗可能通过抑制Survivin、FasL并促进Fas表达来诱导宫颈癌细胞的凋亡。从而达到抑制肿瘤生长、缩小肿瘤体积、降低临床分期及抑制远处转移的目的。硕士研究生董艳(妇产科学)指导教师王蓁教授【关键词】介入化疗;宫颈癌;Survivin;Fas;FasLExpressionofSurvivin,FasandFasLincervicalcarcinomatissuebeforeandafterthearteriafemoralisinterventionalchemotherapyandclinicalsignif
5、icance.AbstractObjeetiveToevaluatedifferentexpressionofSurvivin,FasandFasLincervicalcarcinomacellsbeforeandaftertheartefiafemoralisinterventionalchemotherapyandclinicalsignificance,andtoanalyazetheircorrelationbyexamingtheirpositiveratesinthecervicalcarcinomaandtoinve
6、stigatetherelationsofSurvivin,FasandFasLandtheprocessofinvasionandmetastasisofcervicalcarcinomascombiningtheclinicopathologicalfeatures(surgicalpathologicalstage,histologicaltypeandlymphmetastasis).MethodsSamplesfrom40casesofnormalcervix,30casesofcervicalintraepitheli
7、alneoplasia(ClN)and56cervicalcancerwitllstageIB-IIB,whichincludedtissuesbeforeandaftertheinterventionalchemotherapy,sampleswereexaminedandmarkedthroughPV·6000immunohistochemicalmethodforSurvivin,FasandFasL.Weexaminedtheircorrelationsandrelmions、Ⅳiththeclinicopathologi
8、calstage,histologicalgradeandhistologicaltypeoftheendometrialcarcinomasbyexamingthepositiveratesoftheSurvivin,FasandFasL.Bes
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