壳聚糖基聚电解质载药口服传输体系的-研究

《壳聚糖基聚电解质载药口服传输体系的-研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、摘要时达到最大。模型药物载药实验和体外释药实验结果显示该聚电解质复合物是一种良好的缓释载体。本文创新性地提出了将组织工程支架作为药物控释／缓释的载体，在使支架在修复组织缺陷或缺损的同时，达到治疗疾病的目的，同时能减轻病人的痛苦。关键词：壳聚糖硫酸软骨素聚电解质复合物层层自组装多孔支架AbstractDuetoitsspecialproperties，polyelectrolytecomplexes(PECs)hasbeengivenscoresofattentionintheareaofdrugcontr

2、olreleaseandsomeprogresshavebeenmadeincontrollingreleaseofpeptidedrug，cellimmunity-isolationtransplant，stimulating-reactiondrugcontrolrelease，man-madevaccineandgenetherapy．Chitosan(CTS)，whichistheonlycationicbiopolymer,isanaturalpolysaccharidewithgreatbio

3、compatible，biodegradable，non-toxicandmechanicalproperties．ChondroitinSulfate(CS)isakindofanionicpolymerwhichCanbefoundinthecartilageofanimals，italsohasgreatbiocompatible，biodegradable，non-toxicandgoodmechanicalproperties．Usingthelayerbylayer(LBL)self-asse

4、mblymethod，thisstudypreparedtheCTS／CSPECsbasedontheglassslideandPLAporousscaffolds，respectively．AndthenloadedthemodeldrugontothiskindofPECsanddrugreleaseinvitroWasdone．UsingFT-IRspectroscope，DifferentialScanningCalorimeter(DSC)，ScanningElectronicMicroscop

5、e(SEM)，UltravioletandVisiblespectrophotometer(uv)，thephysicalchemicalproperty,heatpropertyandbiodegradablepropertyofPECswerecharacterized．Alsotheresultsofmodeldrugloadingexperimentanddrugreleaseinvitrowereanalyzed．Themaincontentsandconclusionsareasfollows

6、：1．Basedontheglassslide，CTS／CSPECsfilmWaspreparedusingLBLself-assemblymethod，and5一FuWasloadedontothisPECsandthedrugreleaseinvitroWasdone．TheresultsofFT-IRandDSCindicatethatthereareinteractionsbetweentheCTSaminegroupswiththeCScarboxylateandsulfategroupsthr

7、oughelectrostaticattraction，thoseinteractionsleadtoagoodfilmofPECs．ThedegradationexperimentsindicatethatthedegradationofPECsispHdependent，thereWasslightdegradationintheacidsolutionswhileseveredegradationappearedwhenpHis7．4．Drugreleaseinvitroindicatedthatt

8、hisPECsisagoodcarrierofdrugswithsustainedrelease．2．PLAporousscaffoldswerepreparedbysolutioncasting／particulateleachingtechnique，thencoateditwithchitosan／chondroitinsulfate，5fluorouracilbyIIIAbstractlayer-by-layerass