富血小板血浆应用于年轻恒牙再生性牙髓治疗的动物实验研究

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1、canalinthebloodclotgroup．PreparedPRPwasinjectedintotheasscaffoldinthePI冲group．MTAwasusedforsealingtheaccess．111ecavitywasrestoredwithglassionomercement．X-rayexaminationwasperformedtomonitorthetoothrootdevelopmentaftertreatmentmonthly．3monthslater,theanimalsweresacrificedandperfusedundergeneral

2、anesthesia．111etissueblocksweredecalcifiedandembedded，eachindividualrootWasanalyzedbyhistologicalobservation．Accordingtotheevaluationindex，X-rayandhistologicalobservationwasrecorded．Fisher'sexacttestWasusedforstatisticalanalysis，P-valuelessthan0．05Wasconsideredstatisticallysignificant．Resuits3

3、monthsafterRET,wefoundthattherewerenostatisticaldifferencesinthedecreaseofperiapicalradiolucencies，apicalclosure(P=O．14)，andthickeningofrootwalls俨=O．22)betweenPI冲groupandbloodclotgroupbyX—rayobservation．Histologically,wefoundthattheapicalapexeswereclosed，rootwallswerethickenedandcementum-liket

4、issuesweredepositedonrootwallsandapicalapexinbothPRPgroupandbloodclotgroup．Therewerenostatisticaldifferencesinapicalclosure(P=0．10)，depositionofnewtissuesonrootwalls俨=O．83)andformationofpulp-liketissueinthebetweenPRPgroupandbloodclotgroupbyhistologicalobservation．ConclusionsUsingPRPinRETcouldm

5、akeimmaturepermanentteethdevelopedcontinuously、析mrootwallthickenedandapexclosed．ThereWasnewlyformedcementum—likeandpulp-liketissueinthecanalsbyusingbloodclotandPRPasscaffoldafterRET．DuringRET,iftheperiapicaltissuecouldnottobeirrigatedtobleeding，usingPI冲asascaffoldwouldbeanewchoice．KeywordsImma

6、turepermanenttooth；Regenerativeendodontictreatment；Platelet-richplasma4·英文缩略语·5·论文·富血小板血浆应用于年轻恒牙再生性牙髓治疗的动物实验研究刖吾年轻恒牙牙髓组织不仅具有对牙齿的营养和感觉功能，而且与牙齿的发育密切相关。如果年轻恒牙在牙根未完全发育完成前失去牙髓活力，会导致其根管壁薄弱而易折裂【¨。龋病、牙齿发育异常和牙外伤等因素都可以导致年轻恒牙的牙髓感染和坏死，从而影响牙根的继续发育【21。对于牙髓感染或坏死的根尖孔未闭合的年轻恒牙，临床上传统的治疗选择是使用氢氧化钙(calciumhydroxide

7、，CH)进行根尖诱导成形术【¨。根尖诱导成形术的疗程和效果，不仅取决于牙髓或根尖周病变的程度，还取决于牙根发育状态和患儿的健康状况，其治疗过程较为繁琐，疗程较长。由于治疗前的牙根发育状态和炎症程度不一，诱导后并不是每个病例都能形成正常的牙根形态，有的仅是喇叭口形态的缩小或根尖钙化屏障的形成，而根管壁不再有牙本质硬组织的沉积，因此不能形成正常牙根的长度和足够厚的根管壁，较容易发生牙根折裂【3】。由于根尖诱导成形术存在诸多弊端，学者们一直在探索着新的治疗方法。有学者发现，