非smad通路在小鼠结肠癌肝转移中作用

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1、AdissertationsubmittedtoHuazhongUniversityofScienceandTechnologyfortheDegreeofDoctorofMedicineEffectofnon-SmadpathwayinmousecolorectalcancerlivermetastasisD.Candidate:AiXiMajor:Surgery(GeneralSurgery)Supervisor:ChenXiaopingHuazhongUniversityofScience&TechnologyWuhan430074,P.R.ChinaMay,2012独创性声

2、明本人郑重声明，本学位论文是本人在导师指导下进行的研究工作及取得的研究成果的总结。尽我所知，除文中已经标明引用的内容外，本论文不包含任何其他个人或集体已经发表或撰写过的研究成果。对本文的研究做出贡献的个人和集体，均已在文中以明确方式标明。本人完全意识到本人将承担本声明引起的一切法律后果。学位论文作者签名：日期：年月日学位论文版权使用授权书本学位论文作者完全了解学校有关保留、使用学位论文的规定，即：学校有权保留并向国家有关部门或机构送交论文的复印件和电子版，允许论文被查阅和借阅。本人授权华中科技大学可以将本学位论文的全部或部分内容编入有关数据库进行检索，可以采用影印、缩印或扫描等复制

3、手段保存和汇编本学位论文。保密□，在_____年解密后适用本授权书。本论文属于不保密□。（请在以上方框内打“√”）学位论文作者签名：指导教师签名：日期：年月日日期：年月日目录缩略词表···········································································1前言·················································································3第一部分：CT26-Smad4KD细胞系的建立及鉴定·················

4、····12中文摘要·········································································12Abstract··········································································12绪言···············································································13材料和方法·····································

5、·································13结果···············································································26讨论···············································································29参考文献·········································································29第二部分：干扰Smad4抑制

6、CT26细胞的增殖，促进其凋亡······31中文摘要·········································································31Abstract··········································································32绪言···············································································33材料和方法····················

7、··················································33结果···············································································36讨论···············································································43参考文献··············