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1、ClinicalObservationofyishenpinggancompound'sTreatmentofearlyrenalinjureofessentialhypertensionandmicroalbuminuriaSpecialty：MedicalDepartmentofTCMAuthor：HuangHaiyanTutor：Prof.GaoJiandongAbstractPurpose：Thisstudymonitorsthechangesofthesymptomsandindexesthata
2、rerelatedtotheessentialhypertensionpatientswithearlyrenalinjurebeforeandaftertreatment,toobserveyishenpinggancompound'seffectofinterventionandtreatmenttoearlyrenalinjureofessentialhypertension.Methods：Togather60patientsthatareessentialhypertensionpatientsw
3、ithearlyrenalinjure,allthecasesareoutpatientandinpatientthatcomefromthesecondaffiliatedhospitalofShandongUniversityofTraditionalChineseMedicineinDecember2010toDecember2011.Atotalof60patientswererandomlydividedintoexperimentalgroupandcontrolgroup,eachgrouph
4、ave30cases.Bothgroupswererequestedtobelow-saltdiet,quitsmokingandwine,attendtoappropriatephysicalexercise,etc;combinedhyperlipidemiaandhyperuricaemiatotreatintime.Accordingtothedisease,allpatientsweregivenfelodipinetablets5~10mg/d,onthebasisofantihypertens
5、ivetherapy,ifnecessary,plusmetoprololtablets25~50mg/d.TheexperimentalgroupweregivenyishenpinggancompoundwhilethecontrolgroupweretreatedwithOkracapsules.Courseoftreatmentwere2months.Thelaboratoryparameters,suchasurinarymicroalbumin,urineosmolality,serumcrea
6、tinine(Scr),bloodureanitrogen(BUN),β2-microglobulin,lipidsandsoon,wereobservedbeforeandaftertreatment.Atthetime,wemustobservethechangesof24hambulatorybloodpressure,Clinicalsymptoms,tongueandpluse.Results：Aftertwomonthstreatment,thetotalefficiencyoftheexper
7、imentalgroupis93.3%,thatofthecontrolgroupis66.7%.BytheWilcoxonranksumtest,Z=-2.547,P=0.011,P<0.05，thedifferencewereprominent.Theexperimentalgrouparesignificantlybetterthanthecontrolgroupinimprovingtheclinicalsymptomsofdizziness,headache,backache,nocturia,f
8、iveupsethot,choroidbloodstasis,tongueandpluse,reducingurinaryalbuminandbloodpressure,increasingurineosmolality（P<0.01or0.05）.Conclusion：Yishenpinggancompoundwasprovedtobeeffectivetoimprovetheclinicalsymptoman
