滋阴通络、宣肺布津法对原发性干燥综合征的干预作用及免疫机理研究

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1、ABSTRACTandmeasuredsalivarysecretionvolumeanddacrymavolumeoftherabbits15minutesaftertheinjectionofATuoPintoobservetheeffectofShengJingrainsonsalivarysecretionvolumeanddacrymavolume．(2)WeusedglandulaangularisofSDbigmouseasimmuneantigenadjuvanttoimmuneBacb／csmallmoBge．Weappledmu

2、ltidroinjectionmethod，strengthenedimmuneforfivetimesandduplicatedadjuvantSSsmallmousemodel．Byobservingthepathologycellularchangesofglandulaangularisfeature，weevaluatedtheSuccessofthemodelestablishment．(3)Bacb／csmallmouseweredividedintosixgroupsrandomly：normalcomparisongroup，mo

3、delgroup，LiuWeiDiHuanggroup，highdoseShengJingraingroup，mediumdoseShengJingraingroupandlowdoseShengJingraingroup．Therewasnotreatmentfornormalcomparisongroup．Modelgroupandalltreatmentgroupswerefedmedicinefor60daysfromtheimmuneday．Thesalivarysecretionvolumeofmouseineachgroupismea

4、suredonthe30也，40廿1，50mand60mdaysrespectively．Thechangesinglandulaangularistissues，glandulaa119ularisindex，chestindex，Tlymphocytepositiverate，andtheTandBlymphocyteincreaseandchangeabilityofthespleensofthesmallmouseweremeasuredattheendoftheexperiment．(4)Weusedthesanlemodelestabl

5、ishmentmethod，groupsandmedicines．After60daysofimmune，weusedELISAtomeasuretheIL一1DandTNF—位ofWaiZhoubloodserumofmouseinallgroupstofindtheinfluenceofthismethodonCuYanZhengcellY'mZi．Results：1．Theoreticalresearchresults：Basedontheanalysisofreferencearticles，accordingtotheacademicth

6、oughtsofprofessorJinShi，mysupervisor,webelievethatthebasicBingJiofprimarySjogren’SsyndromeisYinXuLuoZhiandFeiShiXuanBu．ThetreatmentusesZiYinTongLuoandXuanFciBuJinmethod，increasesthecreationofJinYebyenrichingYinYe，andencouragesJinYedistributionandopenJinYechannelbyopeninglungan

7、ddistributingJin，openingLuoandmovingstops．2．Clinicalresearchresults：60PSSsamplesweredividedintotreatmentgroupandcomparisongrouprandomlywith30samplesineachgroup．ThecomparisonofoverallclinicaⅢ砸veeffect：theoveralleffectiverateofShengJingraingroupis83．3％，whichisbetterthantherateof

8、60．7％ofLiuWeiDiHuanggroup，withme踟eddramaticdifference(P<0．05)