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时间:2019-02-08
《2型糖尿病合并非酒精性脂肪肝患者体内的dpp-4水 》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、2型糖尿病合并非酒精性脂肪肝患者体内DPP-4水平研究张叶丽沈莹高平马晓英顾玺杜晓岚汪溯洁陆雷群陈玲通信作者:陈玲邮箱:lwnfm17@163.com作者单位:200020上海,瑞金医院卢湾分院内分泌科【摘要】目的:探讨2型糖尿病合并非酒精性脂肪肝患者体内DPP-4水平与相关因素的关系。方法:选取2型糖尿病组(62例),2型糖尿病合并非酒精性脂肪肝组(62例),分别测量两组患者的身高、体重、腰围、臀围;检测空腹及餐后2小时血糖、C肽,检测糖化血红蛋白(HbA1c),肝功能、血脂;计算其体重指数(BMI)、腰臀比(WHR)、稳态模型评估-胰岛素抵抗指数(HOMA-I
2、R)。结果:1)2型糖尿病合并非酒精性脂肪肝组患者的BMI、WHR、HOMA-IR、血脂(TG、FFA)水平明显高于2型糖尿病组,差异均有统计学意义(P均<0.05)。2)在2型糖尿病合并非酒精性脂肪肝患者中,其空腹及餐后2小时DPP-4水平均明显高于2型糖尿病组,并且差异有统计学意义(P均<0.05)。两组患者的餐后2小时血清DPP-4水平均明显高于其空腹水平,差异均有统计学意义(P均<0.05)。3)2型糖尿病患者合并非酒精性脂肪肝组患者体内的DPP-4水平与体重指数(BMI)、胰岛素抵抗(HOMA-IR)、血脂水平(TG、FFA)、肝损伤指标(ALT、γ-G
3、T)呈正相关(r=0.36,0.32,0.62,0.37,0.48,0.39,P均<0.05)。结论:在2型糖尿病合并非酒精性脂肪肝患者中,DPP-4活性水平高于2型糖尿病患者,并且与胰岛素抵抗、血脂、肝细胞损伤之间都有相关性。【关键词】2型糖尿病;非酒精性脂肪肝;二肽基肽酶IVResearchoftheDPP-4LevelinType2DiabetesMellituswithNonalcoholicFattyLiverDisease【Abstract】Objective:ToinvestigatetheassociationoftheDPP-4levelinty
4、pe2diabetesmellituspatientswithnonalcoholicfattyliverdiseaseandrelatedfactors.Methods:124patientswithdiabetesmellitusweredividedintotwogroups:type2diabeticmellituspatientsgroup(n=62)andtype2diabeticmellituspatientswithnonalcoholicfattyliverdiseasegroup(n=62).Height,weight,waistcircumf
5、erenceandhipcircumferenceweremeasured.Fastingandpostprandialbloodglucose,Cpeptide,HbA1c,liverfunctionandbloodlipidweredetected.Bodymassindex(BMI),waisttohipratioandhomeostasismodelassessment-insulinresistance(HOMA-IR)werecalculated.Results:1)Intype2diabetesmellituspatientswithnonalcoh
6、olicfattyliverdisease,BMI,WHR,HOMA-IR,bloodfatlevelwereobviouslyhigherthantype2diabetesmellitusgroup(P<0.05).2)Furthermore,intype2diabeticmellituspatientswithnonalcoholicfattyliverdisease,thefastingandpostprandial2hoursDPP-4levelsweresignificantlyhigherthanthetype2diabetesmellitusgrou
7、p(P<0.05).Inaddition,postprandial2hoursserumDPP-4levelswereobviouslyhigherthanfastinglevelinbothtwogroups(P<0.05).3)Finally,theDPP-4levelsintype2diabetesmellituspatientswithnonalcoholicfattyliverdiseasewerepositivecorrelationwithBMI,HOMA-IR,bloodlipidlevel,liverinjuryindex(r=0.36,0.32
8、,0.62
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