runx3在结直肠腺瘤、结直肠癌中表达的意义及其与survivin、ki67的相关性研究

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1、英文摘要carriedoutbySPSS17．0statisticalpackageThepositiverateofRUNX3，Survivinandki-67proteinincolorectalcancerwas38．33％(23／60)，73．33％(44／60)，80．00％(48／60)respectively,incolorectaladenomasassociatedwithsevere—gradedysplasiawas43．48％(10／23)，52．17％(12／23)，65．21％(15／23)andincolorectalad

2、enomasassociatedwithLow—gradedysplasiawas72．97％(27／37)，13．51％(5／37)，21．62％(8／37)respectively,andinnormalcolorectaltissueswas86．67％(26／30)，10．00％(3／30)，6．67％(2／30)．RUNX3proteinexpressiondecreasedgraduallyintheadjacentnormaltissue，adenomawithlowgradedysplasia，adenomawithseveredysp

3、lasiaandcolorectalcancertissues．RUNX3proteinexpressionincancertissueswassignificantlylowerthanthatinnormalcolorectaltissueandglandulartumorwithlow-gradedysplasia(P

4、xpressionwassignificantlyhigherthanthatinnormaltissueandlow-gradedysplasiaglandtumors伊<0．05)．Inthe60casesofcolorectalcancerspecimens，therewere23cases，44cases，48caseswithRUNX3，Survivinandki-67proteinpositiveexpressionrespectively．Andamongthe23caseswithRUNX3expression，therewere1ca

5、seswithSurvivinpositiveexpressionand14caseswithki-67positiveexpression．CorrelationanalysisbySpearmanshowedRUNX3andSurvivinorRUNX3andki．67weresignificantnegativecorrelated，whereasSurvivinandki-67expressionpresentedasignificantpositivecorrelation．ThepositiveexpressionrateofheRUNX3

6、andSurvivinmRNAincolorectalcancer,adjacentnormaltissue，adenomawithlowtomoderatedysplasiaandadenomawithseveredysplasiawas40．00％and76．67％，90．00％and6．67％，78．38％and10．81％，43．48％and56．52％，respectivelyandthedifferencewasstatisticallysignificantrP<0．05)．TheRUNX3andSurvivinproteinexpres

7、sionin60casesofcancertissuesampleswas23英文摘要casesand44cases，whileRUNX3andSurvivinmRNAexpresslonwas24casesand46casesrespectively．Whereasinthe30casesofnormalcolorectalmucosaltissue，26casesexpressedRUNX3protein，onlythreecaseswithSurvivinproteinexpression，andRUNX3mRNAexpressedin27cas

8、es，onlytwocaseswithSurvivinmRNAexpression．Fromt