eh患者血清ykl10水泙+与颈动脉内中膜厚度及左室重构的相关性研究

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1、万方数据英文摘要activationandremodelingoftheextracellularmatrix．InVIVO，YKL一401Sexpressedinsmoothmusclecellsofdifferentinflamedtissue，humanvascularadventitia，macrophagessubpopulation，vascularsmoothmusclecellsinatheroscleroticplaquesandatheroscleroticplaqueremodelingmatrix．YKL-40isagoodindependentp

2、redictorofplaquelesions，andhighlevelsofYKL-40affectsthearterialcompliance，andmaybeanewindextoobservesubclinicaltargetorgandamageinhypertensivepatients．StudiesoncorrelationofserumYKL．．40levelswithcarotidintima．．mediathicknessandleftventricularremodelinginpatientswithessentialhypertensionar

3、efew,andthisstudyaimstoexploreit，providingareliablebasisforclinicaltreatmentandprognosis．Methods：199patients(54maleand45female)firstdiagnosedasessentialhypertensionintheSecondHospitalofHebeiMedicalUniversityfromJanuary2014toDecember2014wereenrolledinthisstudy．Thediagnosiswasmadeinaccordan

4、cewith2010ChineseHypertensionPreventionGuide：systolicbloodpressure≥140mmHgand(or)diastolicbloodpressure≥90mmHg(1mmHg20．133kPa)．33subjectswereinthecontrolgroup，allofwhomwerefromthehospitalmedicalcenter,andtheirphrrsicalexaminationswerenormal．Allthepatientshadtheirmedicalhistoryrecordedandh

5、adaphysicalexaminationconventionally．Serumlipids，liverfunction，kidneyfunctionandotherbiochemicalmarkersofthepatientsweretested，inaddition，carotidarteryultrasonographyandechocardiographywereconducted。SerumYKL-40levelsofthesubjectsweredetectedbyimmunohistochemicalstaining．Exclusioncriteria：

6、①olderthan70years②secondaryhypertension⑨accompanyingwithcoronaryheartdisease，diabetes，cardiomyopathy,infection，metabolicdiseases，autoimmunediseasesandseverechronicdiseases@theuncooperative．2CarotidIMTmeasurementmethods：Inthelongaxisofcarotid，themaximumdistanceoftheposteriorarterialwallwas

7、measuredbetweentheinterfaceoflumen．intjmaandmedia-adventitiaatECGR．wavevertex．The万方数据英文摘要measuringpositionincludeddistalcarotidartery,carotidarterybifurcationandwithinthescopeoflcmofproximalinternalcarotidartery．Themeasurementwasperformedinthreecontinuouscardiaccycl