ezh2、bmi-1、fbxw7在食管鳞癌中表达的临床意义

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1、摘要2.BMI-1表达阳性的患者对新辅助放化疗治疗近期疗效的有效率低于其表达阴性的患者；EZH2、FBXW7表达阳性的患者对新辅助放化疗治疗近期疗效的有效率差异不明显。表明在食管鳞癌中检测BMI-1的阳性表达情况可能预测新辅助放化疗治疗近期疗效。3.EZH2、BMI-1、FBXW7的高低表达可能是食管鳞癌新辅助放化疗治疗近期疗效的独立因素；表明检测EZH2、BMI-1、FBXW7的高低表达情况可能是预测新辅助放化疗近期疗效的有效参考指标。4.食管鳞癌中BMI-1与EZH2阳性表达成正相关，说明其在食管恶性肿瘤的发生发展、侵袭和转移等中相互作用，共同参与。关键词

2、：食管鳞癌；EZH2；BMI-1；FBXW7；免疫组化；新辅助放化疗；近期疗效论文类型：应用基础研究选题来源：其他II万方数据ABSTRACTABSTRACTObjective:ToresearchtheexpressionofEZH2、BMI-1、FBXW7inesophagealsquamouscellcarcinomaandadjacentnormaltissue,andexploreEZH2、BMI-1、FBXW7relevancetoneoadjuvantchemoradiotherapyinthenearfuturecurativeeffect.M

3、ethods:SelectalargenumberofesophagealsquamouscellcarcinomaandadjacentnormaltissueswhichwerediagnosedbyendoscopicbiopsyinthefirstaffiliatedhospitalofHenanUniversityofScienceandTechnologyfrom2013.01to2014.05.30casesofcancerandadjacentnormaltissueswereselectedfromwhichwerefirstdiagnose

4、danddidn’tundergoneoadjuvantchemoradiotherapy,andtheexpressionofEZH2,BMI-1andFBXW7wereanalyzedbyimmunohistochemicaltechniqueinthesepatients.AllpatientsweredetectedbybariummealandCTbeforeandaftertreatment.ProspectiveanalysisoftheexpressionlevelsofEZH2,BMI-1,FBXW7andtherelationshipwit

5、htermefficacyofneoadjuvantchemoradiationtherapy.Results:1.ThepositiveexpressionofEZH2inesophagealsquamouscellcarcinoma60%(18/30)washigherthaninadjacentnormaltissue30%(9/30),withstatisticalsignificanceP=0.020(P<0.05);ThepositiveexpressionofBMI-1inesophagealsquamouscellcancer63.3%(19/

6、30)washigherthaninadjacentnormaltissues26.7%(8/30),P=0.004(P<0.05),therewasstatisticallysignificant;ThepositiveexpressionofFBXW7inesophagealsquamouscellcarcinoma40%(12/30)waslowerthaninadjacentnormaltissue80%(24/30),P=0.002(P<0.05),therewasstatisticallysignificant;2.Thepositiveexpre

7、ssionofEZH2,BMI-1,FBXW7inesophagealsquamouscellcarcinomaoftheshort-termefficacyofneoadjuvantchemoradiotherapy.EZH2expressionpositivepatientswithefficient44.4%(8/18)inesophagealsquamouscellcarcinomapatientsbutwithnegativeexpressionefficiencyof66.7%(8/12),P=0.284（P＞0.05）,therewasnosta

8、tisticallysignifica