ppara基因v227a多态性的研究早发2型糖尿病的相关性的研究

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1、TheassociationsofV227ApolymorphismofthePPARalphagenewithearly—-onsetType2diabetesmeilitusAbstractObjective：ToexplorethecorrelationsofPPARaV227Apolyphisminearly-onsetT2DMindalianofChina．Methods：Atotalof496(244menand252women)T2DMsubjectswereenrolledanddivi

2、dedintotwogroups：early-onsetandlate—onsetgroupswhichWeredefinedasdiagnosedal茎40and>40yearsold．Early-onsetT2DMsubjects206(126menand80women)averageagewas36．334-4．02yearsold．Late-onsetT2DMsubjects290(118menand172women)averageagewas56．36a：9．56yearsold．Normal

3、controlgroupsubjectswerecomposedof248healthypeople(112menand136women)．ExtmctedperipheralbloodwhitebloodcellgenomicDNAtodetectPPARaV227ApolymoIphism．PCR-directsequencingwasemployedtodetectthePPARaV227Agenemutationintwogroupsandfrequenciesofgenotypeandalle

4、lewereobserved，andtheclinicalcharacteristicsofmutationgenecarrierswereinvestigated．Resuits：(!)ThefastingplasmaglucoSeffPGgtriglyceride(TG)，uricacid(UA)werehigherinearly-onsetT2DMgroupthaninlate-onsetT2DMgroup．②TheoverallfrequenciesoⅣvVAAAinearly-onsetT2D

5、Mgroupandinlate-onsetT2DMgroupwere92．2％，7．8％，0％，and83．1％，16．9％，0％．Innormalcontrolgroupwere85．9％，12．9％，1．2％．TheV227allelefrequencywas92．2％，andA227allelefrequencyWas7．8％inearly-onsetT2DMgroup，andtheV227allelefrequencyWas83．1％andA227allelefrequencyWas16．9％i

6、nlate-onsetT2DMgroup．Themwerestatisticaldifferencesinthegenetypefrequencyandallelefrequencydistributionbetweenthetwogroups．③Inearly-onsetT2DMgroupA227allelehadlowertotalcholesterol(Tc)、Apo-BthanV227anele．Conclusion：Omearly-onsetT2DMgrouphadpoorerbloodglu

7、cosecontrol，moresevelcIedyslipidemiaandhigheruricacidwhencompared、炳ththelate-onsetT2DMgroup．②Intheearly-onsetT2DMgroupPPARaA227allelefrequencyWaslowerthaninthelate-onsetT2DMgroup．(要)A227variationWaspossiblyprotectivefactorfordyslipidemia．PPARageneV227Apo

8、lymorphismreducededtheriskofhavingearlyon-setT2DMbyreducingthelevelsofTCandAPO·B．@PPARagene．2．V227Apolymorphismwasassociated、们tllearlyon-setT2DMdyslipidemia．Itwasaprotectivefactorofdyslipidemia．Keywords：Early-onsettype2dia