卵巢高级别浆液性腺癌foxm1和gli-1蛋白表达的临床意义

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1、万方数据英文摘要3．2ThecorrelatlonbetweenFOXMlandPCNAproteinexpressionTherewasasignificantpositivecorrelationbetweenFOXM1andPCNAexpression(r--0．402P<0．05)inhi曲一gradeovarianserousadenocarcinoma．InwhichtumorswithhighPCNAexpressionhadasignificantlyhigherexpressionofFOXMI(87．5％V

2、S．62．5％，P<0．05)．3．3ThecorrelationbetweenGli一1andPCNAproteinexpressionTherewasnocorrelationbetweenGli-1andPCNAexpression(r=0．05P>0．05)inhi曲-gradeovarianserousadenocarcinoma，inwhichtumorswithhi曲PCNAexpressionhadanosignificantlyhigherexpressionofGli-1(79．4％Vs．75％，P>0．0

3、5)．4Prognosisinhi曲-gradeovarianserousadenocarcinoma．4．1TherelationshipbetweenFOXMl，GLi—landprognosisinhigh—gradeovarianserousadenocarcinomaAccordingtotheresultoflHCandfollow—update，thesurvivalratesof3and5yearswere(23．8％87．5％)andinhigh—gradeovarianserousadenocarcinom

4、awithFOXM1hi曲expression，significantlylowerthan(4．8％50．O％)inpatientswithFOXMllowexpression．AccordingtotheresultofIHCandfollow—update，thesurvivalratesof3and5yearswere(25．6％63．6％)iIlhigh—gradeovarianserousadenocarcinomawithGLi一1highexpression，significantlylowerthan(5．1

5、％36．4％)inpatientswithGLi一1lowexpression．4．2Therelationshipbetweenclinicpathologicalcharacteristicsandprognosisinhi曲-gradeovarianserousadenocarcinomaAccordingtotheresultofIHCandfollow—update，thesurvivalratesof3and5yearswere(21．9％O)andinhigh-gradeovarianserousadenocar

6、cinomawithFIGO(III／IV)，significantlylowerthan(55．6％33．3％)inpatientswithFIGO(I／II)．AccordingtotheresultofIHCandfollow—update，thesurvivalratesof3and5yearswere(OO)inhigh—gradeovarianserousadenocarcinomawithdistantmetastasis，thesurvivalratesof3and5yearswere(41．5％14．6％)i

7、nhigh—gradeovarianserousadenocarcinomawithnodistantmetastasis3year7万方数据英文摘要andthe5-yearsurvivalratewasstatisticallysignificantdifference俨

8、elofFOXM1，FIGOstagewasidentifiedasanindependentfactorpoorprognosisinpatientswithhigh—gradeovarianserousadenocarcinoma．Conclusion：1Theprote