降粘胶囊的成型工艺、质量标准与初步药效学分析

《降粘胶囊的成型工艺、质量标准与初步药效学分析》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、贵阳中医学院硕士学位论文ABSTRACTObjective：todetermineviscositycapsulepreparationformoldingprocessconditions，thequalitativeidentificationforpreparationofavarietyofingredients：Toestablishcontentdeterminationmethodandqualitystandards．Twoextractionprocessfrompreparationformaximumtolcrated，resistingth

2、rombosis，bloodrheology，pharmacodynamicsexperiment：Determinethepharmacologicaleffectsofthepreparationandfunctionofattending．Methods：usingsoftwarespssl7，optimizinggranulatingprocessconditionswithorthogonalexperiments．Usingthinlayerchromatography(TLC)，tenkindsofeffectivecomponentsinprepa

3、rationforqualitativeidentificatiOn：UsingthesinglefactorinVestigationmethod，theextractionofsalviamiltiorrhizainthepreparationmethod，dosageofextractiontime，extractionsolventwerestudied．UsingHPLCmethoddeterminationoftanshinoneinpreparationtypeIIA，DanphenolicacidscontentofB：Efficacyusingt

4、wokindsofextractionprocessfrompreparationexperiment，usingcapillarymethodwasdevelopedforthedeterminationofviscositycapsuletailcuttingandcoagulationfunctioninvivomethodtomeasureitseffectonbleedingtime，throughthecomprehensiveanalysisoftwokindsofexperimentstheanticoagulantfunctionofviscos

5、itycapsule：Bycomparingtomedicinegroupandmodelgroupratsblood1ipidofthevariousindicators(cholesterol(TC)，triglyceride(TG)，high-densitylipoprotein(HDL)，lowdensitylipoprotein(LDL)，inspectsthedrugtothehyperlipidemiamodelratsfallhematicfataction．Results：1．Thebestmoldingprocess：extractpowder

6、anda—lactoseisbestwith3：2rati0，95％alcoholwetgranule，ovendrying，granulation，capsulesforaquick．．2．Thinlayeridentification，withtheidealofexpansionagent，chromogenicagent，separationeffectisgood，TLCspotswereclear；3．Contentdetermination，2贵阳中医学院硕士学位论文measuredDanphenolicacidscontentshallnotbel

7、essthan4．804mg／Bgranule：TanshinoneIIcontentshallnotbelessthan0．321mg／grainofA．Draftformulatedthequalitycriteriaandqualitystandards．4．Theefficacyexperiment，itcanobviouslyprolongthebleedingtimeandclottingtimeinmice：Experimentalresultsofbloodfat，dosagegroupcomparedwithmodelgroup(p<0．05)，

8、allha