【5A版】研究生英文文献汇报系列.ppt

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1、InfantGutMicrobiomeAssociatedWithCognitiveDevelopment婴儿（2岁时）的认知发育与（特定种类的）肠道微生物有关BiologicalPsychiatry,June2017（online）IF:10.577Yaoxing,2018-01-02ContensBackgroundObjectivesMethodsResultsStrengthsandlimitationsConclusionsWordsrodents（啮齿动物）Gutcolonization（肠道微生物定植）MSEL:MullenScalesofEarlyL

2、earning（马伦早期学习量表）16SribosomalRNAampliconsequencing（16srRNA扩增子测序）alphadiversity（α多样性：α多样性高，肠道菌群比较成熟）theUniversityofNorthCarolinaatChapelHill（北卡罗来纳大学教堂山分校）Co-occurrenceNetworks（共线/同现网络）MetagenomePrediction（宏基因组学预测，利用基因组学的研究策略研究样品所包含的全部微生物的遗传组成及其群落功能）Faecalibacterium（普氏菌）Bacteroides（拟杆菌）Ru

3、minococcaceae（瘤胃球菌/疣微菌科）Background1.Thegutmicrobiomeisacomplexmicrobialecosystemthatvariesbetweenindividualsandmaybeakeymodulatorofneurodevelopmentthroughthemicrobiome-gut-brainaxis（肠脑轴）.2.Inrodents,experimentalmanipulationsthataltertheintestinalmicrobiotaimpactanxietyanddepression-rela

4、tedbehaviors.3.Inhumans,alteredmicrobialcompositionoftheguthasbeenreportedinchildrenwithautismandadultswithdepressionandislinkedtochildhoodtemperamentandadultcognition.4.Nostudieshaveaddressedwhentheserelationshipsemergeordirectlyexaminedwhichbrainregionsmaybeinvolved.5.Arelationshipmay

5、existbetweenconcurrent(同时发生的)gutcolonizationandbraindevelopmentprocesses.Objectives1.Inthisprospective,longitudinalstudy,theresearcherstestedwhetherthe1-year-oldgutmicrobiomewasassociatedwithcognitiveoutcomesat1and2yearsofage.2.Theyhypothesizedthatinfantgutmicrobiomesampleswouldclusteri

6、ntogroupsofcommunitysimilarityandthatcognitiveabilitywoulddifferbetweenclusters.根据群落相似性，肠道菌群样本可以聚类为不同的组，而聚类到不同组的婴儿可能具有不同的认知能力Methods1.StudyPopulationRecruited891-year-oldinfants(twinsandsingletons)fromtwoprospectivelongitudinalstudiesofearlybraindevelopmentattheUniversityofNorthCarolina

7、atChapelHill.两项关于早期大脑发育的前瞻性、纵向研究Exclusioncriteriafortheparentstudiesincludedfetalultrasoundabnormalitiesandmajormedicalillnessofthemother.2.MicrobiomeAnalysis（微生物群分析方法）Parentscollectedapproximately200mgoffecalmaterialfromasinglediaper,placeditinatubefilledwithAllprotectreagent（