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1、健脾益气中药对脾虚大鼠骨骼肌线粒体损伤的保护作用宋雅芳1刘友章2黄晓燕1姬爱冬1宋雅芳，黄晓燕，姬爱冬，广州中医药大学，广东省广州市510405刘友章，广州中医药大学第一附属医院，广东省广州市510405作者贡献分布：此课题由宋雅芳及刘友章设计；研究过程由宋雅芳与黄晓燕、姬爱冬操作完成；研究所用试剂及分析工具由宋雅芳提供；数据分析由宋雅芳完成；本论文写作由宋雅芳、黄晓燕完成。广州中医药大学博士后科研基金资助通讯作者：刘友章，510405，广东省广州市机场路12号，广州中医药大学第一附属医院.liu408@126.com电话：020-36591135Theprotectionofinvig
2、oratingthespleenandtonifyingQiherbsonimpairedmitochondriaofskeletalmuscleinratswithspleenastheniaYa-FangSong,You-ZhangLiu,Xiao-YanHuang,Ai-DongJiYa-FangSong,Xiao-YanHuang,Ai-DongJi,GuangzhouuniversityofChineseMedicine,Guangzhou510405,Guangdongprovince,ChinaYou-ZhangLiu,Thefirstaffiliatedhospitalo
3、fGuangzhouuniversityofChineseMedicine,Guangzhou510405,Guangdongprovince,ChinaSupportedby:Post-doctorscientificresearchfoundationofGuangzhouuniversityofChineseMedicineCorrespondenceto:You-zhangLiu,thefirstaffiliatedhospitalofGuangzhouuniversityofChineseMedicine,Guangzhou510405,Guangdongprovince,Ch
4、ina.Liu408@126.comAbstractAIM:ToobservetheeffectsofinvigoratingthespleenandtonifyingQiherbsonmitochondriasuccinatedehydrogenase,cytochromeoxidaseactivityofskeletalmuscleinratswithspleenasthenia.METHODS:TheratsinthemodelgroupwerefedwithhalffullandperfusewithXiaochengqiDecoctioneverydaytobuildanima
5、lmodelofspleenasthenia.40SDratswererandomlydividedinto4groups:normalcontrolgroup,modelofspleenastheniagroup,sijunzidecoctiongroupandhuangqisijunzidecoctiongroup.Generalstateofratswereobserved,thechangesofmitochondriasuccinatedehydrogenase,cytochromeoxidaseactivityofskeletalmuscleweremeasuredbybio
6、chemicalmethod.8RESULTS:Comparedwithnormalcontrolgroup,thelevelofSDHandcytochromeoxidaseactivityofskeletalmusclemitochondriainspleenastheniagroupweredecreasedobviously（27.112±7.104VS44.328±5.894,3.029±0.501VS4.455±0.767,bothP＜0.01）；WhileHuangqisijunzidecoctiongroupandsijunzidecoctiongroupcanenhan
7、cethelevelofSDH（41.426±4.700VS27.112±7.104，38.419±3.873VS27.112±7.104，bothP＜0.01）andcytochromeoxidaseactivityofskeletalmusclemitochondriacomparedwithmodelgroup（4.234±0.577VS3.029±0.501，4.002±0.491VS3.029±0.501，bothP＜0.
