正常人手运动相关脑区功能连接的fmri分析

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1、天津医科大学硕士学位论文Abstractobjective：FunctionalconnectivityfMRlwereperformedinnormalsubjectstoinvestigatetheconstitutionofhandmotor-relatedbrainnetwork，toanalyzeandcomparethefunctionalconnectivityofmotor-relatedbrainnetworkbetweentherestingstateandtaskstate，tosievesignificantnodesinthenetwork，

2、torevealethedynamicchangesofthenetworkfromtherestingstatetotaskstateandtoelucidatethemechanismsofmotorfunctionalrecoveryasnormalcontr01．Methods：Sixty-onesubjectswererecruitedinthisstudy．GE3．0THDXMRScannerWasusedtoobtainhighresoluationanatomyimagesandfMRIdatainrestingandtaskstate．Tasksta

3、teWasblock—designedfMRlwithbothhandsmotion．SPM2wasusedtoprocessflVlRIdata．Pre—processingincludeslicetiming，realign,normalizationandsmooth．GroupanalysisWasperformedwithsinglesamplet-test．Finally，activatedmappingWasoverlappedontostandardMNItemplate．Locations，MNIcoordinateandactivatedinten

4、sityofacitivedbrainareaswererecorded．Activedbrainareasintaskstatewereselectedasseednodes．Matlab7．0wasusedtocalculatetheconnectivitycoefficient(Z)andconnectivitydegree．Results：Bilateralsupplementarymotorcortex(SMA)，primarymotorcortex(M1)，dorsalpremotorcortex(PMd)，ventralpremotorcortex(PM

5、v)，putamen(Pu)，thalamus(1m，cerebellumanteriorlobe(CbAL)，cerebellumposteriorlobe(CbPL)weresignificantlyactivatedintaskstate，whichconsistedofamotor-relatedbrainnetwork，andwereselectedasseednodes．FunctionalconnectivityanalysiswagperformedbaSedontheseseednodes．Therewere105couplesoffunctiona

6、lconnectivityin15seednodes．Therewere68couplesofsignificantconnectivitycoefficientinrestingstate，105couplesofsignificantconnectivitycoefficientintaskstate(IZl>0)．Therewere63significantcouplesofsignificantconnectivitycoefficientinrestingstate，105couplesofsignificantconnectivitycoefficient

7、intaskstate(1Z[>__0．10)．Therewerejust45couplesofsignificantconnectivitycoefficientinrestingstate，103couplesofIII2．3．Thereisacomplexedmotor-relatedbrainnetworkinbothrestingandtaskstates，whichiSconsistedofseveralmotor．relatdbrainareas．BilateralMls，PMds，rightCbAL，andrightCbPLweret