长期单侧感音神经性耳聋患者的全脑功能与结构mri分析

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1、万方数据ASTUDYUSINGTHEFUNCTIoNALANDSTRUCTUALMAGNETICRESoNANCEIMAGINGoNPATIENTSWITHLoNG．TERMEDUNILATERALSENSoRINRURALHEARINGLoSSPostgraduate：FENGYuanSupervisor：LIUBinMedicalSchool，SoutheastUniversityAbstractobjectiveSensorineuralhearingloss(SNHL)isusedtoreferthediseasewhichbroughttheh

2、earinglossbythelesioninthepathwayoftheauditorysyStem．ThisstudycombinedthersfMRIandstructuralMRjtoanalyzethedatacollectedfromtheHLgroupofpatients谢t11long—termedunilateralsensorineuralhearinglossandthenormalgroup．Methods19patients、析Ⅱlunilateralsensorineuralhearinglossand35subjects、

3、柝mnormalhearingwererecuited．DataofM砌ofallsubjectswerecollectedaftertheinformedconsentsighed．Theseed—basedmethodWasusedtoprocessthersfMR／datatoobservethefunctionalconnectivitybetweendifferentbrainareasandtheprimaryauditorycortex．AndthepartialcorrelationanalysesofthestructuralMIUan

4、dclinicalindexweremadetofindthepotentialrelevance．ResultsSignificantlyincreasedordecreasedfunctionalconnectivitybetweenafewbrainareasandthePACwereshown．Andthesignificantcorrelationbetweenthestandardizedvolumeofsomebrainareasandclinicalindex(1evelofdeafnessandageatonsetofdeafness)

5、wereconfirmed．ConclusionThefunctionalcompensatorychangesWasdemonstratedbythersfMRIandstructuralMRI．Simultaneously,thisplasticitymaybecorrelated、析ththeclinicalindex．【Keywordl：Sensorineuralhearingloss；Restingstatefunctionalmagneticresonanceimaging；Functionalconnectivity．II万方数据目录中文摘

6、要⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯I英文摘要⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯II论文目录⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯ⅡI缩略词表⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯Ⅳ第一章前言⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯1第二章综述⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯2第三章实验对象及方法⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯12第四章实验结果⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯19第五章讨论⋯⋯⋯⋯⋯⋯⋯⋯⋯

7、⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯24第六章结论⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯28参考文献⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯29致谢⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯40作者简介及发表文章⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯41III万方数据缩略词RESTMIUBOLDsMRIEPIUSNHLSPMICAReHoALFFFCEEGPETPACSACHLABRCT缩略词表英文全称resting-statefunctionalmagneticresonanceimagingb

8、loodoxygenleveldependentstructuralmagnet