微泡增强的超声空化消融犬前列腺的实验-研究

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1、第三军医人学硕士学位论文英文缩写英文全称AIAUCBPHCEUSDABEBHEHIFUISPTALMMBSMEUSMIPBSPITEMTICTUNELTUSUSVEGF英文缩写词一览表ApoptosisindexAreaundercurveBenignprostatichyperplasiaContrastenhancedultrasoundDiaminobenzidineEvansblueHematoxylin—EosinHighintensityfocusedultrasound中文全称凋亡

2、指数益线下面积良性前列腺增生症超声造影二氨基联苯胺伊文思蓝苏木素一伊红高强度聚焦超声Spatial—peaktemporal—averageintensity空间峰值时间平均声强LightmicroscopeMicrobubblesMicrobubbleenhancedultrasoundMechanicalindexPhosphatebufferedsolutionPeakintensityTransmissionelectronmicroscopeTimeintensitycurve光学显微

3、镜微泡微泡增强的超声机械指数磷酸盐缓冲溶液峰值强度透射电子显微镜时间强度曲线Terminaldeoxynucleotidyltransferase末端脱氧核苷酸转移酶介导的mediateddUTPnickendlabelingdUTP缺口末端标记技术TherapeuticultrasoundUltrasound治疗超声超声Vascularendothelialgrowthfactor血管内皮生长因子第三军医大学硕士学位论文ProstateAblationusingMicrobubbleEnhan

4、cedUltrasoundCavitation：anExperimentalStudyonCanineModelAbstractBackgroundsBenignprostatichyperplasia(BPH)isacommondiseaseofagedmen，featuredwithprogressivedysuria．BPHisoneofthemainreasonsofbladderoutletobstructionbecausetheurethramaybestressedandmayl

5、eadtoretention，hydronephrosisandevenbladderandrenaldysfunctionwhichmayseverelyreducelifequalityThereareseveralmethodsforBPHtreatment，includingmedication，surgeryandminimallyinvasivetherapy．Withtheemergingandfastdevelopingofnovelultrasoundtherapytechni

6、quesinrecentyears，moreandmorestudiesfocusedonablationofBPHusingtherapeuticultrasound(TUS)，includinghighintensityfocusedultrasound(HIFU)andhistotripsy．Acousticcavitationisoneofthemajorphysicaleffectsofultrasound．Microbubble(MB)enhancedultrasound(MEUS)

7、cavitationcaninduceshockwave，micro-jetsandothermechanicaleffects，whichmayleadtomicrovasculardisruption，hemorrhageandthrombosis．SinceMBcanonlytravelinbloodvessels，likeredbloodcell，thedamageeffectsofMEUSmainlyhappentothevascularwall．BPHisahyperplasticd

8、iseasewithabundantneovasculaturewhichhappensininnergland．Theneovasculatureusuallygrowswithmanydevelopmentaldefectsanditisphysicallyvulnerable．ThismakesthemechanicaldisruptionpossiblebyusingMEUS．Inthepreviousstudy，wefoundMEUScanmakesignificantdamageto