乳腺肿块ct灌注成像与vegf、mvd相关性的-研究

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1、PS、M如平均值高于VEGF阴性组，其ePBF、PS之间的差异具有统计学意义。结论乳腺CT灌注成像可对肿瘤的MVD、VEGF进行评价，对于良恶性肿块的鉴别及恶性肿块的分期及预后评估有重要的参考价值。关键词体层摄影术；xe_y计算机；乳腺2·英文论著摘要·CorrelationbetweenCTperfusionimagingandExpressionofVascularEndothelialGrowthFactor(VEGF)andMicrovesselDensity(MVD)inBreastmassesObjectiveTheaimofthisstudyistoev

2、aluatethecorrelationbetween64一CTperfusionimagingandExpressionofVascularEndothelialGrowthFactor(VEGF)andMicrovesselDensity(MVD)inbreastmasses．Methods64一CTperfusionimagingofthebreastwasperformedin20breastmasses(12breastmalignantmasses．8breastbenignmasses)、析t11pathologicallyverified．64一CTp

3、erfusionWasperformedonSOMATOMSensation64(Siemens，Germany)，ThedatawereprocessedbysyngoBodyPCT(Siemens，Germany)softwarepackage，andthemeanbloodflow(BF)、bloodvolume(BV)andpermeability(PS)withinregionofinterest(ROI)weremeasured。ThecorrelationsofCTperfusionparameterswithexpressionofVEGFandMVD

4、wereanalyzed．ResultMeanvaluesofBF、BV、PSofBreastmalignantmassesare1．045士0．301ml／ml／min、0．175士0．675ml／ml、0．501士0．149ml／ml／min，meanvaluesofBF、BV、PSofbreastbenignmassesare0．346士0．181ml／ml／min、0．082士0．045ml／ml、0．235士0．127ml／ml／min，breastmalignantmassesshowhighervaluesofBF、BV、PScomparedtobrea

5、stbenignmassesbytheindependentsampleftest(P

6、l／ml／min、32．OO士4．63、26．92-士4．58，mealavaluesofBF、BV、PS、MVDandLVNincentralofbreastmalignantmassesare0．852+0。206ml／ml／min、0．161+0．050ml／ml、0．392土O．142ml／ml／min、26．92+4．58、13．08+3．09．ThevaluesofBF,PSincaseswithVEGFpositivityweresignificanthigherthatofVEGFnegativity(P

7、、PSandMVDofVEGFpositivemassesare0．935+0．392ml／ml／min、O．155+0．074ml／ml、0．471+0．176ml／ml／min、33．92+11．94，meanvaluesofBF、BV、PSandⅣ【VDofVEGFnegativemassesare0．510-a：0．380ml／ml／min、0．091+0．077ml／ml、0．280士O．162ml／ml／min、23．38士11．76．ConclusionCTperfusionparametersofbreastmassesareclos