哌拉西林他唑巴坦在肾脏内科患者中的群体药动学与药效学-研究

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1、英文摘要哌拉两林他唑巴±Ll在肾脏内科患者中的群体药动学及药效学研究Populationphall『】1acokineticsandpharmacodynamicsresearchofpiperacillin／tazobactaminpatientsinObjectiVenepnrOJOgVdeDartment．Iv，1AbstractPiperacillin／tazobactamhasbeenwidelyusedininfectiousdiseasesofthenephrologydepanment．HoweVer，tllerenalmncti

2、onimpaimentjsverycommoninthepatientsofnephrologydepaIrtment．Asaspecialgroup，thesepatients’dmgdispositionprogressisnotonlydi行．erentf而mothergroups，butalsoshowsawideVariancewithinthegroup，wmchmakesitnecessa巧toadjusttheindividualizeddosageregimenofantibioticsbasedonthephmnacokine

3、tics(PK)andphamaco-dynamics(PD)propenies．Inthjsstudy，anHPLCmethodwasestablishedforthedete肌inationofthepiperacillinandtazobactaminhumanplasmaofpatientswithdi虢rentrenal向nction；aIldnonlinearmixede脏ctmodelⅢ0MⅥEM)methodwasusedtoestablishthepopulationpha肌acokinetics(PPK)modelofpipe

4、racillill／tazobactaminthespecific伊oupofnephrologydepanment．TllisPPKmodelmakesithighlypossibIetodesignrationaldosageregimensforindividualsduringami—infectivetherapy．MethodsDetemlinationoft11epiperacillin／tazobactaminplasmabyHPLC：Themobilephaseforpiperacillinwas0．01mol。L～sodium

5、dihydrogenphosphate(pH6．5)。acetonitrile(75：25，V／V)，andwas0．01mol’L．1sodiumdihydrogenphosphate(pH6．5)．acetonitrile(90：10，V／V)fortazobactam．Otherc11romatographicconditionsincluded：nowrate(1．0m1．min-1)，columntemperature(30℃)，detectionwaVelen百h(220Illll)andinjectionVolume(20pL)．T

6、hespecificity，linearcorrelation，recoveⅨprecisionandstabili哆wereevaluated．Establismentandauthenticationofpopulationphamacokineticmodelinthepatientsofnepllrologydepanment：PatientswereeIlrolledaccordingtotheinclusionTV哌拉两林他唑巴坦住’肾脏内科患者中的群体药动学及药效学研究英文摘要andexclusioncriteriaandaUt11

7、eparticipantssignedtheinf．o珊edconsentbefbretreatment．Di俄rentdosageregimensweregiVenaccordingtotheseVerityofinfection，theresultsofbacterialcultureandtherenalmnction．WhensteadystatewasreachedinpatientswithintraVenousinjectionaRerthreedays，Venousbloodsampleswerecollectedbeforeth

8、einjection，O．5hand1～6haRerinjection．Bloodsamplesofeachpatientshouldb