六味地黄汤对糖尿病肾病大鼠肾脏保护作用的.研究

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1、^昧地赞汤jt船尿病肾病大鼠肾咀保护作用的研究英文摘要ProtectiveeffectofRehmanniaeDecoctionofSixIngredientsOilrenalfunctionofratswithdiabeticnephropathyPostgraduare=wangxiangMajor：ClinicofintegratedtraditionalandwesternmedicineSupervisor：associateprofessorolosuilinABSTRAcTObjectiveThroughobservi

2、ngtheeffectofRehmanniaeDecoctionofSixIngredientsonthebodyweight，kidneyweight，indexofkidneyhypertrophy(kidneyweightl／bodyweight)，bloodglucose，serum1ipid(totalcholesterin，triglyceride)，kidneyfunction(serumcreatinine，bloodureanitrogen)，urinaryB2一microglobuli，urinary[=n-ac

3、etyl—B—d—glucosaminidase]andurinarymicro—albuminondiabeticratsinducedbyfeedingwithhighglucoseandhighfatandinjectingstreptozotocin(STZ)intoabdomen。toinvestigatetheactingmechanismofRehmanniaeDecoctionofSixIngredientsandprovideanexperimentalbasisforclinicalmedicatingandfo

4、rfuturedevelopmentofRehmanniaeDecoctionofSixIngredientsMethodsThe52femaleSDratswererandomlydividedinto5groupsaccordingtotheirweight：8ratswereinthenormalcontrolgroup，9ratswereinLotensingroup，12ratswereinthepathologygroup，12ratswereinthelowdosegroupandl1ratswereinthemedi

5、umdosegroup．8ratsinthenormalcontrolgroupwerefedwithnormaldiet．RatsintheDMgroupwerefedwithhighglucoseandhighfat．After4weeks，weinjected—IV—A味地黄汤对耱尿病肾病大鼠肾脏保护作用的研究英文摘要streptozotocin(STZ)intoabdomenofratsintheDMgroupwiththedoseof30mg／kg，andratsintheDMgroupwerestillfedwithhi

6、ghglucoseandhighfat．Aweeklater，bloodglucoseofratsintheDMgroupwastested．Thoseratswhosebloodglucosewasup16．7mmol／Lwereinto嗍group．andwehaveonehundredpercentofSuccess．ThentheywerefedbyintragastricadministrationwithmediumdoseRehmanniaeDecoctionofSixIngredients，lowdoseRehman

7、niaeDecoctionofSixIngredients，Lotensinsuspensionandnormalsalinerespectivelyeveryday．Thenormalgroupwasfedbyintragastricadministrationwithnormalsaline，too．Duringthetreatment，weobservedtheirgeneralcondition，suchaseating，drinking，excretionandSOOIL8weekslater，wecollectedthe

8、irurine．Afterkilled，theirbloodwascollectedandtestedthebloodglucose，Tc，TG，LDL-C。HDL吒，ScrandBUN。Andal1ratsweretestedbod