和中消溃汤对乙酸溃疡模型大鼠胃粘膜保护作用的.研究

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1、lnvestigationofHezhongxiaokuiDecoction’8protectiveeffectongastricmucosaoftheratsWithUIcerinducedbyAcetiOAcidSpeciaIity：TraditionaIChineseMediOiReAuthor：0iJing—jingTutor：WangXian—binABSTRACTObjective：ToinvestigatetheprotectiveeffectofHezhongxiaokuidecoctiOilongaStriCmuco

2、saofratSwithu1CCTinducedbyhcetiCAcid．ToStudyitStherapeutiCeffectaswellastheposSiblemechanism．Andtoprovideac1inicarationaefortTeatmentofgaStriCUcer．Methods：i0of70maiehea1thyadultratSfromqua1it弱range200—2509．werechoosedtoformthenormalcontrolgroupatrandoⅡLTheOtherSwerealli

3、nducedchroniCgaStriCUcerbyAcetiCAcid．(inject30pl100％AcetiCAcidattheSubserosaofjunctureoftheventra1aspectcorpusgastricumofStomachusg1andu1arisandgaStriCantrumtoformawhitenodu1ewithapproxhatediameterof3mm)．Atthe4thdayaftermodling10ratSwerechoosedtOevaluatewhetherthemodlew

4、assuccessful．IfSUCCCSSrateswasgreaterthan80％．successfulmodlewasseenestablished．Theleft50ratsweredevidedinto5groupsatrandom：Modelgroup、highdosegroupof4Hezhongxiaokuidecoction(25．29／Kg*d)、mediumdosegroupofiaokuidecoction(12．69／Kg*d)、1oK’dosegroupofHezhongxiaokuidecoction(

5、6．39／Kg*d)、LizhuDelegroup(O．369／Kg*d)．RatsofHezhongXiaokuidecoctiongroupandLizhuDelegroupwereintragastricadministratedHezhongXiaokuiPhysic1iquorsandLizhuDe1ePhysicliquorsrespectivelY，onetimeperday，total1y16days．Theotherswereintragastricadministratednormalsa1ine．16days1a

6、ter，A11theratswereexecutedtocoi1ectbloodtodetectthecontentofP1asmaET，andrats’sbe1Ywerecutopenandremovedthestomachtos1icethescarofu1certissue．AfterHEdyeingandPASdyeingseparate1Yweobservedthehealingconditionoftheulcegandmeasuredthethicknessofregenerativemucosa，Mean职，hi1e，

7、WedetectthecontelltofNO、MDA、SOD、EGF、6-Keto-PGFlaofstomachtisue．Atlastwecomparedthedifferenceofinterc1asandana1yzeddatabySPSSstatisticsoftware．Results：I．Thedeterminationthethicknesoftheregeneraticemucosaonchronicgastriculcerratshashowedthatcomparedwithmode1group．thethick

8、nesofgastricmucosaincreasedsignificant1YineachdoseofHezhongXiaokuigroupandLizhuDelegroup(P<0．05—0．01)，Highdose