冠脉内预防性应用山莨菪碱对急性下壁心肌梗死患者直接经皮冠脉介入治疗后冠脉微循环的影响

《冠脉内预防性应用山莨菪碱对急性下壁心肌梗死患者直接经皮冠脉介入治疗后冠脉微循环的影响》由会员上传分享，免费在线阅读，更多相关内容在应用文档-天天文库。

1、中文摘要及P=-0．12)。超声心动图检查：术后一周时山莨菪碱组与对照组LVEF及WMS无明显差别(尸>O．05)，一个月时山莨菪碱组LVEF(60．5土8．1VS．56．4+6．9)及WMS(1．8士0．7VS．2．1+0．6)均较对照组改善(尸O．05)。结论：冠脉内预防性应用山莨菪碱可明显改善急性下壁心肌梗死患者直接PCI术后冠脉微循环灌注水平，保护心功能；且可稳定血流动力学，有效预防过缓性再灌注心律失常的发生。关键词：山莨菪碱；急性下壁心肌梗死；直接经皮冠脉介入术；冠脉微

2、循环；再灌注心律失常；预防性冠脉内给药英文摘要ThepreventiveeffectsofintracoronaryadministrationofanisodamineoncoronarymicrocirculationafterprimaryDerCUtane0UScoronaryInIe．interventioninacutenormyocarOlal·‘●●●●‘l-’●n·●J●inIarctlonDatlentSABSTRACTobjectives：Toexplorethepreventiveeffectsofintracoronaryadministrationo

3、fanisodamineoncoronarymi、crocirculationinpatientswithacuteinferiormyocardialinfarction(alMI)．Methods：FromMarch201toDecember2012，atotalof92patientsunderwentprimaryPCIwithin12hoursfromtheonsetofAIMlwereenrolled．Allsubjectswerewellpreparedwithoxygen，electrocardiogram(ECG)monitoringaswellasadequ

4、ateanticoagulationandantithrombotictreatment．AfterCoronaryArteryAgiography(CAG)，thepatientswererandomlyassignedtoreceiveanisodamine(groupA，n-47)orplacebo(groupB，n=45)．Intracoronaryanisodaminewasadministeredimmediatelywhenantegradeflowwasregained，whilepatientsincontrolgroupreceivedintracorona

5、ryadministrationof0．9％sodiumchloridewiththesamevolumeasanisodamingroupinthesameway．Allpatientswereplacedindrug—elutingstentsbythestandardofbeyond75％ofluminalstenosis．Duringtheprocedure，theTIMImyocardialperfusiongrade(TMPG)andcorrectedTIMIframecount(CTFC)oftheculpritvesselwererecoded，SOastoev

6、aluatecoronarymicrocirculationperfusion．Thepeakofcreatininekinase—MB(CK—MB)andtroponinI(cTnI)werecompared．Leftventricularejectionfraction(LVEF)andwallmotionscore(WMS)wereobservedatoneweekandonemonth．Theindicatorsabovewereusedtoevaluatethepreventiveeffectsofintrocoronaryinjectionofanisodamine

7、onmyocardialinfarctionsizeandventricularfunction．Theincidenceofreperfusionbradyarrhythmiaandmajoradversecardiacevents(MACEs)inhospital，includingcardiacdeath，non—fatalreinfarction，severeheartfailureandtargetvesselrevascularization，wererecordedtoasse