欢迎来到天天文库
浏览记录
ID:31947727
大小:430.39 KB
页数:22页
时间:2019-01-29
《stemi患者直接pci术中抗凝治疗》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、重庆医科大学硕士研究生学位论文行的抗凝治疗方案的建议。关键字:比伐卢定,肝素,STEMI,直接PCI3万方数据重庆医科大学硕士研究生学位论文ANTICOAGULATIONTHERAPYINSTEMIPATIENTSDURINGPRIMARYPCIABSTRACTCoronaryheartdisease(CHD)istheoneofleadingcausesofdeathintheworld.Themainmechanismismyocardialischemiaandhypoxiathatcausedbycoronaryatheroscl
2、erosisluminalstenosisorobstruction.Andacutecoronarysyndrome(ACS)isanacuteclinicaltypeofCHD.Onthebasisofcoronaryatherosclerosis,whenatheromatousplaquecrackorbreakitexposethematerialthatwillleadtothrombosistothebloodstream.Thereforeitcausesplateletadhesiontoformthethrombus,
3、resultinginlesions’vesselscompleteorincompleteocclusion.SothekeytreatmentofACSliesinantithrombotictherapy.ForpatientswithST-segmentelevationmyocardialinfarction(STEMI),standardtreatmentisintendedtoquicklyreopentheblockedartery.Accordingtotheguidelinestheuseofprimarypercut
4、aneouscoronaryintervention(PPCI)isrecommendedforpatientswithSTEMIwhohaveanonsetofsymptomsoflessthan12hourswithin90–120minutes.SeverebleedingeventsareassociatedwiththeprognosisinACSpatientsafterPCI.Therefore,reducingbleedingcomplicationsisasimportantaspreventingischemiceve
5、nts.Alargenumberofclinicaltrialshaveprovedthatbivalirudin(asadirectthrombininhibitor)cannotonly4万方数据重庆医科大学硕士研究生学位论文reduceischemiceventsbutalsoreducebleedingevents,especiallyforNSTEACS(nonSTsegmentelevationacutecoronarysyndrome)patients.Thisadvantagehasbeenwidelyrecognized
6、.ButfortheacuteSTsegmentelevationmyocardialinfarction(STEMI)patientswhowillacceptprimaryPCI,itremainstobeahottopicthatwhetherheparinorbivalirudinisbetterforanticoagulation.ThispaperisaimedatsummarizingthemainresearchprogressonthetreatmentstrategyofprimaryPCIinSTEMIpatient
7、swithanticoagulation.BycombiningwiththecurrentactualsituationinChina,finallywewishtoprovidesomefeasiblesuggestionsforanticoagulationtreatment.Keyword:bivalirudin,heparin,STEMI,primaryPCI5万方数据重庆医科大学硕士研究生学位论文STEMI患者直接PCI术中抗凝治疗前言目前,冠心病仍然是全球死亡率最高的疾病之一。急性冠脉综合征(ACS)是冠心病的严重类型。无论
8、是欧洲还是美国的指南均推荐ACS患者早期介入治疗[5-7]联合抗栓药物治疗。其中包括双重抗血小板药物(阿司匹林和ADP受体拮抗剂)和恰当的抗凝治疗。一直以来,抗凝治疗方案的选择都是保证经皮冠状
此文档下载收益归作者所有