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1、检测不孕不育患者血清中AsAb和ACA的临床意义(镇江市第二人民医院江苏镇江212002)【摘要】目的：探讨对不孕不育势女检测抗精子抗体(AsAb)和抗心磷脂抗体(ACA)的临床意义。方法：收集2014年7月〜2015年6月在我院诊断诊断为不孕不育的102对夫妇为观察组，随机选取同期进行健康检查的90对正常生育夫妇为对照组。对比分析两组研究对象AsAb和ACA的阳性率。结果：对照组90例男性AsAb阳性数2例(2.2%),ACA阳性6例(6.7%),对照组90例女性AsAb阳性数1例(1.1%),ACA阳性2例(2.2%),观察组102例男
2、性AsAb阳性35例(34.3%),ACA阳性12例(11.8%)观察组102例女性AsAb阳性28例(27.5%),ACA阳性27例(26.5%)。与对照组比，观察组男性与女性的AsAb阳性例数较多，女性的ACA阳性例数较釦P<0.05)o对照组势性与女性AsAb阳性均为IgG型，不孕男性与女性的IgM型AsAb阳性率明显高于IgG型、IgA型和lgG+lgM(P<0.05)o对照组男性与女性ACA阳性均为IgG型，不孕男性与女性的IgG型分明显高于IgM和lgA(P<0.05)o结论：AsAb和ACA是造成患者不孕不育
3、的重要因素，AsAb-IgM抗体类型表达相对较多，是影响不孕不育重要的免疫性抗体，对不孕不育的诊断有重要的临床意义。【关键词】AsAb；ACA；不孕不育【中图分类号】R446.62【文献标识码】A【文章编号】2095-1752(2016)29-0165-02TheClinicalsignificaneeofdetectionofAsAbandACAininfertilityZengGuangjian,LuGuangren,LiuZhuomin,XinhuacommunityhealthservicecenterinHuaduDistrict
4、ofGuangzhouCity(XinhuaHospital)510800,China【Abstract]ObjectiveToinvestigatetheclinicalsignificaneeofdetectionofantispermantibodies(AsAb)andanticardiolipinantibody(ACA)inmaleandfemaleinfertility.MethodsFromJuly2014-2015yearinJune,102infertilitycouplesinourhospitalwereselect
5、edinourstudy.90healthycoupleswerecollectedasthecontrolgroup.AsAbandACAin2groups,andspermgeneralexaminationofallmalecasesweredeterminedandcompared.ResultsIn90casesofcontrolgroup,2casesmaleAsAband6casesmaleACAweredeterminedwiththepositiveratesof2.2%and6.7%,respectively.1case
6、smaleAsAband2casesmaleACAweredeterminedwiththepositiveratesof1.1%and2.2%,respectively.In102casesofobservationgroup,35casesmaleAsAband12casesmaleACAweredeterminedwiththepositiveratesof34.3%and11.8%,respectively.28casesfemaleAsAband27casesfemaleACAweredeterminedwiththepositi
7、veratesof27.5%and26.5%,respective!y.Comparedwithcontrol,themaleandfemalecasesofAsAbandfemaleACAinobservationgroupweremore(P<0.05).Inthecontrolgroup,mostAsAbmaleandfemalecaseswereIgG.Intheobservationgroup,mostAsAbmaleandfemalecaseswereIgM.MostACAmaleandfemaleintwogroupsw
8、ereIgG.ConclusionAsAbandACAaretwoimportantfactorscausinginfertility.DeterminationofAsAb-I
