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1、MicrobialInhabitantsofHumansTheindigenousmicrobiota(or“normalmicroflora”)comprisesthosemi-crobesthatinhabitthehealthyhumanbody.Manyoftheseorganisms(e.g.,Streptococcuspyogenes,Staphylococcusaureus,Neisseriameningitidis,Haemophilusinfluenzae,andEscherichiacoli)
2、areresponsibleforcommon,andsometimeslife-threatening,infectionsofhealthyindividuals,whereasotherscausedis-easeonlywhenthebody’sdefensesareimpaired.Thisadvancedtextbookprovidesauniqueoverviewofthemicrobialcom-munitiesinhabitingthoseregionsofthehumanbodythatare
3、exposedtotheexternalenvironment;theseincludetheskin,eyes,oralcavity,andtherespi-ratory,urinary,reproductive,andgastrointestinaltracts.Tounderstandwhyparticularorganismsareabletocolonizeananatomicalregionandwhytheresultingmicrobialcommunityhasaparticularcompos
4、ition,anecologicalapproachisessential.Consequently,thekeyanatomicalandphysiologicalcharacteristicsofeachbodysitearedescribedtoshowhowtheseinfluencethenatureoftheenvironmentatthatsite.Thecrucialrolesoftheindigenousmicrobiotainprotectingagainstexogenouspathogen
5、s,regulatingthedevel-opmentofourimmunesystemandmucosae,andprovidingnutrientsarealsodiscussed.Theinvolvementoftheseorganismsininfectionsofhealthyanddebilitatedindividualsaredescribedthroughout,andmethodsofma-nipulatingthecompositionoftheindigenousmicrobiotafor
6、thebenefitofhumanhealtharediscussed.MicrobialInhabitantsofHumansisacoretext-bookforadvancedstudentstakingcoursesinmicrobiology,medicalmicro-biology,microbialecology,andhumanbiology.MichaelWilsonisProfessorofMicrobiologyintheFacultyofClinicalSciencesandHeadoft
7、heDepartmentofMicrobiologyattheEastmanDentalInstituteatUniversityCollegeLondon.HeistheEditor-in-Chiefofthejour-nalBiofilmsandhascoauthoredoreditedseveralbooks,includingBacterialDiseaseMechanisms(2002),BacterialAdhesiontoHostTissues(2002),andMedicalImplication
8、sofBiofilms(2003).iiiMicrobialInhabitantsofHumansTheirecologyandroleinhealthanddiseaseMichaelWilsonUniversityCollegeLondoniiiPUBLISHEDBYTHEPRESSSYNDICATEOFTHEUNIVERSITYOFCAMBRIDGEThePittB
