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1、GRP78在人喉鳞状细胞癌组织中的表达及临床意义张灵敏田秀芬(450052郑州,郑州大学第一附属医院头颈外科)[摘要]目的探讨葡萄糖调节蛋白78(glucose-regulatedprotein78,GRP78)在人喉鳞状细胞癌(laryngealsquamouscellcarcinoma,LSCC)组织中的表达情况,分析GRP78在LSCC发生发展中的作用。方法免疫组织化学法检测GRP78在90例LSCC组织、配对癌旁组织及正常喉黏膜组织中的表达,并分析其与患者性别、肿瘤分化程度、分期及淋巴结转移的关系。结果G
2、RP78在LSCC组织、配对癌旁组织及正常喉黏膜组织中的阳性表达率分别为86.67%、32.22%、8.89%,三者的差异具有统计学意义(P<0.05)。GRP78的表达与LSCC的分化程度、分期及淋巴结转移均密切相关(P值均<0.05),与性别无关(P>0.05)。结论GRP78在LSCC中呈高表达,表达水平随癌组织恶性程度的增高而增高[关键词]人喉鳞状细胞癌;葡萄糖调节蛋白78;免疫组织化学Expressionofglucose-regulatedprotein78inhumanlaryngealsquamo
3、-uscellcarcinomaanditsclinicalsignificanceZhangLingmin,TianXiufen(DepartmentofHeadandNeckSurgery,FirstAffiliatedHospital,ZhengzhouUniversity,Zhengzhou,HenanProvince,450052,China)[Abstract]ObjectiveToinvestigatetheexpressionofglucose-regulatedprotein78(GRP78)i
4、nhumanlaryngealsquamouscellcarcinoma,andtoevaluateitsroleinthedevel-opmentprogressofhumanlaryngealsquamouscellcarcinomaMethodsTheexpressionsofGRP78inhumanlaryngealsquamouscellcarcinoma,matchedpairpericarcinomatoustiss-ueandnormallaryngealsquamousepithelialtis
5、suefrom90patientsweredetectedusingim-munohistochemistryanalysis.Inaddition,therelationshipbetweenGRP78expressionandcl-inicalparametersofpatients,suchasgender,tumordifferentiationgradestage,andlymphaticmetastasiswasanalyzed.ResultsThepositiveratioofGRP78expres
6、sioninLSCC,matc-hedpairpericarcinomatoustissueandnormallaryngealsquamousepithelialtissuewere86.67%,32.22%and8.89%.TheGRP78expressionsindifferenttissuesweresignificantlydiffere-nt(P<0.05).GRP78expressioninLSCCtissueswascorrelatedwiththegradeofdifferentio-n(P<0
7、.05),stageoftumors(P<0.05),andlymphaticmetastasis(P<0.05),butnotwithgender(P>0.05).ConclusionsTheexpressionlevelofGRP78proteininhumanlarynge-alsquamouscellcarcinomaishighanditsexpressionispositivelyassociatedwiththemalign-ancyofcarcinoma.[Keywords]humanlaryng
8、ealsquamouscellcarcinoma;glucose-regulatedprotein78(GRP78);immunohistochemistryCorrespondingauthor:TianXiufen,E-mail:xiufen.tian@126.com喉鳞状细胞癌(laryngealsquamouscellcarcinomaLSCC)是喉部最常见的恶性