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1、作者简介：周芳珍，女，壮族，副主任医师。研究方向：精神科疾病的诊断与治疗。单位：530001，广西南宁市第五人民医院（Author:：Zhoufangzhen,female,Zhuang,seniordeputydirectorofthephysician.ResearchInterests:diagnosisandtreatmentofpsychiatricdisorders.ThefifthPeople’sHospitalofNanning,Guangxi530001）哌罗匹隆联合甲状腺素治疗原发性甲减所致精神障碍疗效观察周
2、芳珍，谢焱，程琳(广西南宁市第五人民医院精神科，南宁530001)【摘要】目的：探讨哌罗匹隆联合甲状腺素治疗原发性甲减所致精神障碍的疗效及安全性。方法：使用哌罗匹隆联合甲状腺素或左-甲状腺素钠片治疗甲减所致精神障碍34例，采用阳性和阴性症状量表(PANSS)及不良反应症状量表(TESS)于治疗前后进行评定，并在疗程结束后比较治疗前后血促甲状腺激素（TSH）、三碘甲状腺元氨酸（T3）、甲状腺素（T4）、游离三碘甲状腺元氨酸（FT3）、游离甲状腺素（FT4）的变化情况。结果：哌罗匹隆联合甲状腺素或左-甲状腺素钠片治疗后PANSS总分
3、明显下降，治疗前与治疗后第2,4,8周比较差异有统计学意义(P<0.01)。病情疗效评定：总有效率88.2%。治疗后TSH、T3、T4、FT3、FT4明显好转，与治疗前比较，差异有统计学意义(P<0.01)。结论：哌罗匹隆是一种安全有效的抗精神病药物，对精神症状有显著的改善作用。联合治疗原发性甲减所致精神障碍病人是安全有效的。关键词哌罗匹隆精神障碍原发性甲减甲状腺素内分泌疾病【中国图书分类法分类号】R581.1【文献标志码】A【收稿日期】2012-3-7ObservationonthecurativeeffectsofPeros
4、pironeandwiththyroxineinthetreatmentofmentaldisorderscausedbyprimaryhypothyroidismZHOUFangzhen,XIEYan,CHENGLin(DepartmentofPsychiatric,theFifthPeople’sHospitalinNanning)【Abstract】Objective:ToexplorethecurativeeffectsandsafetyofPerospironeandwiththyroxineinthetreatmen
5、tofmentaldisorderscausedbyprimaryhypothyroidism.Methods:Totally34patientswithmentaldisorderscausedbyhypothyroidismweretreatedbyPerospironecombinedwiththyroxine,orleft-levothyroxinesodiumtablets.Thepositiveandnegativesymptomscale(PANSS)andadversesymptomsscale(TESS)wer
6、eusedtoassessthecurativeeffectsbeforeandafterthetreatment.Thechangesofbloodthyroidstimulatinghormone(TSH),iodinethyroidacid(T3),thyroxine(T4),freeiodinethyroidacid(FT3)andfreethyroxine(FT4)beforeandafterthetreatmentwerecompared.Results:PANSStotalscoresweredecreasedsi
7、gnificantlyaftertreatingbyPerospironecombinedwiththyroxine,orleft-levothyroxinesodiumtablets,withsignificantstatisticaldifferencesbeforethetreatmentandat2,4,8weeksafterthetreatment(P<0.01).Diseaseefficacyevaluation:thetotaleffectiveratewas88.2%.Afterthetreatment,TSH,
8、T3,T4,ofFT3andFT4weresignificantlyimprovedccomparedwiththosebeforetreatment(P<0.01).Conclusions:Perospironeisasafeandeffectiveantip
