资源描述：
《320株鲍曼不动杆菌的临床分布及耐药性分析》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、320株鲍曼不动杆菌的临床分布及耐药性分析安宝清1王金侠2［摘要］目的：了解我院年鲍曼不动杆菌医院内感染分布特点及耐药趋势，为制定预防和控制其医院感染的措施提供依据，并指导临床合理使用抗生素。方法：常规分离我院细菌，采川美国Walk-away-40全自动细菌鉴定仪进行菌株鉴定。采用琼脂纸片扩散法（K・B法）对临床分离株进行药敏实验，参照CLSI判断标准，采用标准菌株人肠埃希菌ATCC25922、铜绿假单胞菌ATCC27853为质控菌株，用WHONET5.4统计软件进行数据处理和分析。结果：共分离鉴定鲍曼不动杆菌320株，从痰标木屮分离261株，占81.6%,其次从
2、伤口分泌物标木屮分离19株，占5.9%,在血液及脑脊液屮的分离率分别为16株（5.0%）及6株（1.9%）。我院鲍曼不动杆菌对头孑包哌酮/舒巴坦的耐药率为59.1%,左旋氧氟沙星为74.6%,莫西沙星为75.3%,亚胺培南为79.7%,对其它12种抗生索的耐药率均大于80%；泛耐鲍曼不动杆菌（PDRAB）检出率为33.1%。结论：鲍曼不动杆菌已成为我院医院感染尤其是ICU感染的主要病原菌，且耐药形势严峻；对泛耐药的鲍曼不动杆菌感染的患者应以头抱哌酮/舒巴坦第一线抗菌药物；鉴于对亚胺培南的高耐药率，应慎用碳青霉烯类药物。［关键词］鲍曼不动杆菌；医院感染；耐药性Cli
3、nicaldistributionandresistancecharacteristicanalysisof320AcinetobacterbaumanniistrainsAnBaoQing,WangJinXia:DepartmentofClinicalLaboratoryTests,ChangLiHospitalofChineseMedine,QinHuangDaoSecondHospital,Hebei,066600［Abstract］Objective:Toanalysistheclinicaldistributionandresistancecharact
4、eristicsinisolatesofAcinetobacterbaumannii（Ab）,andprovideevidenceforclinicalpreventionandtherapy.MaterialsandMethods:RoutinebacteriacultureandAmericanWalkaway・40identificationsystemwereadoptedforbacteriaidentification.SusceptibilitywastestedbyKirby一Bauermethod,referingtoSLSIcriterion,
5、employingEscherichiacoliATCC25922andPseudomonasaeruginosaATCC27853asthestandardstains.AnalyzethedatabyWHONET5.4software.作者：1河北省昌黎县中医院检验科2秦皇岛市第二医院检验科河北昌黎066600Results:Themajorityofisolateswerefromsputum(261strains,accountfor81.6%),followedbywoundsecretion(19stains,5.9%);thenblood(16sta
6、ins,5.0%)andcerebrospinalfluid(6stains,1.9%).TheresistaneeratetoCefoperazoneandSulbactamis59.1%,Levofloxacin74.6%,moxifloxacin75.3%)andImipenem79.7%.theresistaneratestootherantibioticsarehigher(>80%).Thedetectionrateforpandrug-resistantAcinetobacterbaumanniiis33.1%.Conclusions:Acineto
7、bacterbaumaniigreatlycontributestonosocomialinfections,especialyinICUward・Andthesituationofdrug-resistaneewassevere・Totreattheinfectionofdrug-resistantAcinetobacterbaumanii,itisadvisedtoemployCefoperazoneandSulbactamasthefirstlinedrug.InviewofthehighrateofresistancetoImipenem,carbopen
8、emssh
