英文：一例长期应用帕米磷酸和唑来膦酸发生股骨骨折的病例报道

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1、HSSJ(2008)4:123–127DOI10.1007/s11420-008-9077-4CASEREPORTCaseReportofSpontaneous,NonspinalFracturesinaMultipleMyelomaPatientonLong-termPamidronateandZoledronicAcidGregWernecke&SurenaNamduri,MD&EdwardF.DiCarlo,MD&RobertSchneider,MD&JosephLane,MDReceived:13May2008/Accepte

2、d:13May2008/Publishedonline:16July2008#HospitalforSpecialSurgery2008AbstractPamidronateandzoledronicacidaretwopotentactionofosteoclastsandpreventingboneresorption,intravenousbisphosphonatesusedinthetreatmentofbisphosphonateshavebeenshowntoreducebonycompli-multiplemyelom

3、aaswellasosteoporosis.Whilethecationsandfracturesinpatientswithmultiplemyeloma[1–concernforheightenedfractureriskinapatientonlong-7].Inaddition,bylimitingendostealresorption,bonetermbisphosphonatetreatmentformalignancyhasbeenmarrowexpansionofmyelomacellsmaybeinhibited.p

4、reviouslynoted,wepresentthefirstcaseofspontaneous,Zoledronicacidisanitrogen-containingbisphosphonatethatnonspinalfracturesinapatientundergoingtreatmentforinhibitsenzymesofthemavelonatepathwayandconse-multiplemyeloma.Thepatienthadapositive9-yearhistoryquentlyinhibitspreny

5、lationofsmallguanosinetriphosphate-ofbisphosphonatetreatmentandpresentedwithsequentialbindingproteins,whicheventuallyleadstosecondarysubtrochantericstressfracturesoftheleftandrightfemurs.osteoclastapoptosis[8–11].Duetoitshighpotency,thisPathologicalreportsoffracturesite

6、biopsiesdemonstratebisphosphonatehasbecomethefirstoptioninthetreatmentsignsconsistentwithametabolicboneandnomalignancy.ofmalignancy-inducedhypercalcemiaandosteoporosis.ItsThesefindingspointtoextremeinhibitionofboneturnoverefficacyandsafetyhavebeendemonstratedinrandomizedby

7、bisphosphonatesasthecauseofthispatient’smorbidity.clinicaltrialsusingbreastcancer,multiplemyeloma[12–Thisisasingleretrospectivecasestudy(levelIVevidence).13],lungcancer,andprostatecancerpatients[14].WhileoralbisphosphonateshavealonghistoryofKeywordslong-termbisphosphona

8、tetherapy.successfuluseinthetreatmentofnonmalignancy-associatedstressfracture.multiplemyeloma.osteoporosisoste