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1、TheOxfordTextbookofClinicalResearchEthicsThispageintentionallyleftblankTheOxfordTextbookofClinicalResearchEthicsEDITEDBYEzekielJ.EmanuelChair,DepartmentofBioethics,NationalInstitutesofHealth,Bethesda,MarylandChristineGradyHead,SectiononHumanSubjectsResearch,DepartmentofBioe
2、thics,NationalInstitutesofHealth,Bethesda,MarylandRobertA.CrouchThePoynterCenterfortheStudyofEthicsandAmericanInstitutions,IndianaUniversity,Bloomington,IndianaReidarK.LieProfessorofPhilosophy,UniversityofBergen;Head,UnitonMultinationalResearch,DepartmentofBioethics,Nationa
3、lInstitutesofHealth,Bethesda,MarylandFranklinG.MillerBioethicist,NationalInstituteofMentalHealthIntramuralResearchProgram,DepartmentofBioethics,NationalInstitutesofHealth,Bethesda,MarylandDavidWendlerHead,UnitonVulnerablePopulations,DepartmentofBioethics,NationalInstituteso
4、fHealth,Bethesda,Maryland120081OxfordUniversityPress,Inc.,publishesworksthatfurtherOxfordUniversity’sobjectiveofexcellenceinresearch,scholarship,andeducation.OxfordNewYorkAucklandCapeTownDaresSalaamHongKongKarachiKualaLumpurMadridMelbourneMexicoCityNairobiNewDelhiShanghaiTa
5、ipeiTorontoWithofficesinArgentinaAustriaBrazilChileCzechRepublicFranceGreeceGuatemalaHungaryItalyJapanPolandPortugalSingaporeSouthKoreaSwitzerlandThailandTurkeyUkraineVietnamCopyrightª2008byOxfordUniversityPress,Inc.Chaptersbythefollowingauthorsareinthepublicdomain:Agrawal,B
6、onham,Denny,Emanuel,Goldkind,Grady,Killen,Miller,Resnik,Rosenstein,Schron,Temple,Varma,Weed,WendlerPublishedbyOxfordUniversityPress,Inc.198MadisonAvenue,NewYork,NewYork10016www.oup.comOxfordisaregisteredtrademarkofOxfordUniversityPressAllrightsreserved.Nopartofthispublicati
7、onmaybereproduced,storedinaretrievalsystem,ortransmitted,inanyformorbyanymeans,electronic,mechanical,photocopying,recording,orotherwise,withoutthepriorpermissionofOxfordUniversityPress.LibraryofCongressCataloging-in-PublicationDataTheOxfordtextbookofclinicalresearchethics=e
8、ditedbyEzekielJ.Emanuel...[etal.].p.;cm.Includesbibliographicalreferencesandindex.