hif-1αbnip3信号通路调节的低氧诱导自噬在唾液腺腺样囊性癌中的作

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1、分类号：-R62单位代码：10422密级：公开学号：2012120358⑧．厶茹只孥博士学位论文(专业学位)论文题目：HIF．1Q／BNIP3信号通路调节的低氧诱导自噬在唾液腺腺样囊性癌中的作用THEEFFECTOFHYPoXIAINDUCEDAUToPHAGYMEDIATEDBYHIF．1a／BNIP3SIGNALINGP．ATHⅥ恰YlNADENnIDfYSTTffARfTNoMA作者姓名陈占伟学院名称山东大学医学院专业学位名称外科学(整形外科)指导教师张东升教授合作导师2015年5月3日万方数据原创性声明本人郑重声明：所呈交的学位论文，是本人在导师的指导下

2、，独立进行研究所取得的成果。除文中已经注明引用的内容外，本论文不包含任何其他个人或集体已经发表或撰写过的科研成果。对本文的研究作出重要贡献的个人和集体，均已在文中以明确方式标明。本声明的法律责任由本人承担。论文作者签名：陋日期：肌关于学位论文使用授权的声明本人同意学校保留或向国家有关部门或机构送交论文的印刷件和电子版，允许论文被查阅和借阅；本人授权山东大学可以将本学位论文的全部或部分内容编入有关数据库进行检索，可以采用影印、缩印或其他复制手段保存论文和汇编本学位论文。(保密论文在解密后应遵守此规定)论文作者签名：醴导师签名万方数据目录中文摘要“1英文摘要“5符号

3、说明“9第一部分低氧诱导唾液腺腺样囊性癌ACC—M细胞自噬的实验研究材料与方法16结果21讨{仑24参考文献26第二部分低氧条件下抑制自噬过程观察腺样囊性癌ACC—M细胞侵袭的实验研究材料与方法29结果·3l参考文献·35全文结论37综述38致谢48攻读博士学位期间发表的学术论文情况49学位论文评阅及答辩情况表“50英文论文一51英文论文二71万方数据CoNTENTSAbs缸lactinCllinese···············································．1Abstrad···············”·一·······

4、·····一··一6Abb托viatedwords9Pref-ace‘··············································．11PanICobaJtchlorideinducedACC-Mcellsauto铲aphexperimentaIresearchMaterialsandMetllods16Results··············-······································．21Djscussion····································．24Ref

5、-erences·································．26PartIIChlorineinhibitedautophagyprocesstosuppresstumorinVasionMaterialsandMethods···································．29Results··············································-．3lDiscussion····································．33R-efIerences。··

6、···································．35Conclusion·······················．37ReView·················································．38Acknowledgement··········‘····························-。’。·····_48Publishedresearchpapers···············‘····‘。。。。。’。。·t49DissenationdefenseaIldreview-·

7、··························巧OEn91ishl)aper1····。。。‘········‘‘。·····‘····。。’。。‘··’。‘。‘··巧lEn91ishpaper2············。‘·····。·‘·····。···················-··．71万方数据山东大学博士学位论文F一1Q／刚lP3信号通路调节的低氧诱导自噬在唾液腺腺样囊性癌中的作用研究生：陈占伟专业：外科学研究方向：整形外科导师：张东升教授中文摘要唾液腺腺样囊性癌(salivaryadenoidcysticcarcinoma，SACC)是头

8、颈部唾液腺最常见的恶性肿