骨折合并脑外伤时il-10对骨折愈合的影响

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1、中文摘要关键词:脑外伤:股骨骨折;IL-I0IIAbstractAbstractobjects：ToevaluatetheserumIL-10and啊NF—ccaftertraumabraininjurycombinedfracture．IL一10whetherhaveapromotingeffectonthehealingofbonefracture．Methods：I203-month·oldmaleSDrats(weight195—2109)wererandomlydividedinto4groupsaccordingtorando

2、mnumbertable．Eachgrouphas30rats．Theyweredealedwiththe4methodsasfollows：GroupA：traumabraininjurycombinedfemoralfracture；GroupB：traumabraininjurysingly；GroupC：therightfemoralfracturewithinjectingIL一10(1099／Kg·d)in2weeks；GroupD：therightfemoralfracturewithinjectingPBS(1m1)in2

3、weeks．Atthe6mhour,24mhourand48mhourpost—injury,ratsofGroupCandGroupDweredeterminatedtheIL一10andTNF．0tlevelsintheserumbyELISAmethod．Atthe1轧day．4们day,7‘“dayand14thdaypostoperative，liverandkidneyfunctionindexeswereexaminedofGroupCandGroupD．Atthe2∞week，4”1week，6‘“weekpostoper

4、ative，X—rayswerenecessarytookofratsfromGroupCandGroupDtoevaluatethebonecallusvolume，what’Smore，wealsofetchedthetissuenearthefracturefragmentstoHEdyed，Massonstainandimmunohistochemicalexamination。Allofthestatisticaldatasareexpressedasmean士standarddeviation(_土s)．Ttestwasuse

5、dtoanalysisthedata．UsingIBMSPSS19．0softwaretodataanalysis．P<0．05asastatisticallysignificantdefference．Results：1．NSSscore：atthe6mhour,thescorereachedthepeakandtheaveragescorewas11．01士1．82．Graduallythefunctionofthetraumabraininjuryrecoverytonomal礤er1month．2．ThecontentsoflL．

6、10：Atthe6’hhour,24‘hhourand48‘hhourpost··injury,thecontentsofIL--10illGroupAwashigherthaninGroupBandGroupD，anditwashigherinGroupBthaninGroupD，P<0．05．3．ThecontentsofTNF—Q：Atthe6‘“hour,24‘“hourand48mhourpost．injury,thecontentsofTNF—ainGroupAwashigherthaninGroupBandGroupD，P<

7、0．05，however,itwasnodifferencebetweenGroupBandGroupD．4．ThecallusonX—rays：atthe2edweek，4‘“weekandAbstract6mweek，thebonecallus’SvolumeinGroupCwaslargerthaninGroupD，P<0．05．5．Atthe18‘dayand4mdaypostoperative．theliverandkidneyfunctionindexeswerehigherthannormal．Whileatthe7‘“da

8、y,theindexeshadreturnedtonormalinGroupCandGroupD．6．Histologicalexamination：Fibroblastcellsandcar