茴香提取液对酒精性胃黏膜损伤的保护作用

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1、-w-香提取液对酒精性胃黏膜损伤的保护作用【摘要】目的探究茴香对小鼠酒精性胃黏膜损伤的保护作用方法用56°北京红星二锅头白洒建立小鼠酒精性胃黏膜损伤模型，用茴香进行干预，30天后，眼球采血测血淸超氧化物歧化酶（S0D）活性和丙二醛（MDA）水平；观察胃黏膜损伤指数，HE染色，观察胃黏膜组织形态学的改变。结果与正常组相比，模型组胃黏膜损伤指数、MDA水平明显升高（P〈0.01）,SOD活性明显降低（P〈0.01）;胃黏膜表层大部分腺体形态及结构不完整，可见大量腺体结构破坏、脱落。与模型组相比，茴香高剂量组和西咪替丁组胃黏膜损伤指数、MDA水平均明显降低（P<0.05或0.01），SOD

2、活性显著升高（P〈0.05），苘香屮剂量组MDA水平明显降低（P〈0.01）;茴香中剂量组和高剂量组胃黏膜表层腺体结构较完整，茴香高剂量组细胞坏死较少。结论茴香可能通过降低脂质过氧化、增加机体氧化应激能力对酒精胃黏膜损伤进行保护。【关键词】茴香；酒精；胃黏膜损伤；氧化应激；超氧化物歧化酶;丙二醛屮图分类号：R573；R965文献标识码：AD0I:10.3969/j.issn.1003-1383.2017.03.003[Abstract]ObjectiveToexploretheprotectiveeffectsoffennelonalcoholicgastricinjuryinmic

3、e.MethodsThemodelofalcoholicgastricmucosainjurywasestablishedby56°BeijingRedStarErguotouWineandintervenedwithfennelfor30days,andthen,bloodfromeyeballwascollectedtotestserumsuperoxidedismutase(SOD)activityandmalondialdehyde(MDA)levels.Inaddition,thegastricmucosalinjuryindexandHEstainingaswellast

4、hemorphologicalchangesofgastricmucosawereobserved.ResultsComparedwithnormalgroup,gastricmucosalinjuryindexandthelevelofMDAinmodelgroupincreasedsignificantly(P〈0.01),buttheactivityofSODdecreasedobviously(P<0.01)•Themorphologyandstructureofmostglandsinthesurfaceofgastricmucosawereincomplete,andit

5、couldbeseenthatalargenumberofglandstructuresweredamagedanddetached.Comparedwiththemodelgroup,gastricmucosalinjuryindexandthelevelofMDAinfennelhighdosegroupandcimetidinegroupdecreasedobviously(P<0.05or0.01)，buttheactivityofSODincreasedsignificantly(P<0.05).ThelevelofMDAinfennelmediumdosegroupdec

6、reasedsignificantly(P<0.01).Thestructureofglandsinthesurfaceofgastricmucosainthefennelhighdosegroupandthefennelmediumdosegroupwerecomplete,andthefennelhighdosegroupshowedlessnecrosis.ConclusionFennelcanprotectagainstgastricmucosaldamagebyreducinglipidperoxidationandincreasingoxidativestressinth

7、ebody.［Keywords］fennel；alcohol；gastricmucosainjury；oxidativestress；SOD；MDA?S着生活水平的不断提高，人们饮酒的问题越来越严重，同时过量饮酒造成的消化系统问题也越来越受到人们关注。文献报道长期过量饮酒可以引起胃炎、胃溃疡、十二指肠溃疡等［1］。酒精是一种有机溶剂，高浓度的酒精可以使胃黏膜上皮细胞发生坏死，从而破坏胃黏膜的防御系统，使胃黏膜容易受到各种损伤因子的侵袭而受到损害［2］。伞形