原发性肝癌中brms1蛋白和caⅰ蛋白表达及其临床病理意义

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1、七年制硕士学位论文英文摘要ABSTRACTObjeetiveToinvestigatetheeXPressionofBreastCaneerMetastasisSuPPressorl(BRMSI)ProteinandCarbonie内止ydrasel(CAI)ProteininPrimaryHePaticCarcinoma(PHC)，andtoeXPloretherelationshiPsofthemselvesandtheeorrelationbetweenthemandtheclinieoPathologicalcharae

2、teristicsofPHC.MethodsThesPeeimensfrom47PatientswithPrimaryHePatieCarcinoma(PHC)and20eorresPondingParaneoPlastichePatictissueswerefixedin10%formalinandroutinelyembeddedinParaffin.Thespeeimenswereeontinuouslyslieedinto4卿一thicksections.EnvisionTMimmunohistoehemistrywas

3、PerformedtodeteettheexPressionsofBRMS1ProteinandCA1Proteinwithmonoelonalantibodiesandscoredthemunderhigh一PowermicroscoPy.ResultsInthe47PrimaryHePatieCareinoma(PHC)eases，therearesignifieantlystatisticaldistinctionsintheexPressivePositiverateandtheeXPressivescoresofBRM

4、S1andCA1ProteinbetweencaneertissuesandParaneoPlastietissues(P<0.01，P<0.05).TheeaneertissueswithintrahePatiemetastasisandtumorthrombosishavesignifieantlylowerexPressivePositiverateandexPressiveseoresofBRMS1proteinthantheothers(p<0.01，p<0.05)，andalsothereisasinifieantl

5、ylowerPositiverateinnodularanddiffusePHCthanmassive七年制硕士学位论文英文摘要ones(P<0.05).Butwehaven’tfoundtherelatioshiPsbetweenB侧MSIandothermainelinieoPathologiealeharaeteristicsofPHC(P>0.05).There15nocorrelationbetweentheexPressionofCA1ProteinandclinieoPathologiealeharaeterist

6、iesofPHC，exeePtthattheeXPressivePositiverateandtheeXPressivescoresofPHCsignificanilygraduallyinereasewiththedescendingdifferentiationdegree(P<0.05).There15noevidentcorrelationbetweentheexPressiveseoresofBR五江51ProteinandthatofCA1ProteinineaneertissuesofPHC(r=-0.37，尸>0

7、.05).ConclusionThelostexPressionofBRMS1ProteininPHCPlaysanimPotantroleintheinvasiveandmetastatieProeess，withouteffeetonthetransformationandgrowthofPHC.Ontheeontrary，theovereXPressionofCA1ProteininPHC15eloselyrelatedtothedifferentiation，anditmayhavenothingtodowiththeg

8、ro叭h、invasivenessandmetastasis.Andthere15noeorrelationbetweentheeXPressiveseoresofBRMS1ProteinandthatofCA1ProteinineaneertissuesofP