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ID:27659011
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时间:2018-12-05
《卵黄囊瘤32例临床病理分析》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、【摘要】0的:探讨卵黄囊瘤(yolksactumour,YST)的临床病理特征、免疫组化特点、诊断及鉴别诊断,以提高对YST的认识。方法:回顾性分析2008-2015年本院确诊的32例YST患者的临床病理特征及免疫组化染色结果,并复习相关文献,进行对比总结。结果:32例YST患者中男19例,女13例,年龄7个月〜50岁(平均12.6岁),肿瘤发生于睾丸17例,卵巢10例,性腺外5例。病理标本镜检可见到特征性的S-D小体,疏松网状结构,及细胞内外的透明小体。免疫表型可见32例Glypican-3、CK、SALL4均(+),CD30、hCG、CD117、
2、EMA、CD15、CK7、ER、PR均(-),28例AFP(+),20例vimentin(+),5例PLAP(灶+),2例OCT4(灶+),Ki-67增殖指数大于50%o结论:YST是一种少见的生殖细胞肿瘤,发生于性腺外时容易误诊,可依靠组织学特点及免疫组化结果进行明确诊断。【关键词】卵黄囊瘤;临床病理;鉴别诊断;免疫组织化学中图分类号R730.45文献标识码B文章编号1674-6805(2016)17-0048-03【Abstract】Objective:Toimprovethecognitionabouttheyolksactumor(YST)b
3、yexploringtheclinicopathologicalcharacteristics,immunohistochemicalcharacteristics,diagnosisanddifferentialdiagnosisofYST.Method:Thirty-twocasesofYSTwereselectedandtheclinicopathologicalcharacteristicsandimmunohistochemicalstainingwereretrospectiveanalyzed,andtherelevantliterat
4、urewerereviewedandcompared.Result:Amongthe32caseswithYST,19casesinmales,13casesinfemale,theaverageyearsoldwas12.6rangingfrom7monthsto50yearsold.Astotheoccurrencesite,17caseswerefoundintestis,10caseswerefoundinovaryand5caseswerefoundinextragonadalsites.Themicroscopicalresultshow
5、edcharacteristicSchiller-Duvalbodies,loosereticularstructureandhyalinedropletsinthetumortissue.TheimmunohistochemistryshowedGlypican-3,CKandSALL4wereexpressedinallofcases,whileCD30,hCG,CD117,EMA,CD15,CK7,ERandPRwerenotexpressedinallofthecases.TheexpressionofAFPwithdifferentleve
6、lswerefoundin28cases.Vimentinwereexpressedin20cases.ThespottyexpressionofPLAPwasshowedin5cases.ThespottyexpressionofOCT4wasshowedinonly2cases.TheproliferativeindexofKi-67wasmorethan50%.Conclusion:YSTisararegermcelltumor,whichiseasytobemisdiagnosedwhenappearedinextragonadalsites
7、.ThecorrectdiagnosisofYSTismainlydependedonhistopathologyandimmunohistochemicalstaining.【Keywords】Yolksactumor;Clinicalpathology;Differentialdiagnosis;ImmunohistochemistryFirst-author'saddress:ProvincialClinicalMedicalCollegeofFujianMedicalUniversity,Fuzhou350001,Chinadoi:10.14
8、033/j.cnki.cfmr.2016.17.025卵黄囊瘤(YST)又名内胚窦瘤,是一种起源于原始生殖细
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