分化型甲状腺癌（dtc）术后131i治疗最佳出院时间的研究

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1、分化型甲状腺癌(DTC)术后1311治疗最佳出院时间的研究倪发强(浙江省肿瘤医院核医学科浙江杭州310022)【摘要】目的：探讨分化型甲状腺癌(DTC)患者术后1311治疗住院时间的相关问题。方法：以58例甲状腺切除术后行1311治疗的甲状腺乳头状癌患者为研究对象，分为低剂量治疗组27例(治疗剂量为3700MBq＞和高剂量治疗组31例(治疗剂量7400MBq)n分別测量患者服药后48h、72hlm距离处的放射性辐射剂量，同时以400MBq的1311作为参考放射源。结果：低剂量治疗组和高剂量治疗组服药后48h放射性辐射剂量差异有统计学意义(t=2.311,P=0.028

2、)"所有患者服药后72h的放射性辐射剂量均低于参考源，17例患者(低剂量治疗组5例,高剂量治疗组12例｝服药后48h的放射性辐射剂量高于参考源。结论：分化型甲状腺癌(DTC)患者行1311治疗后72h的放射性辐射剂量迅速下降，且明显低于国家规定的400Mb的辐射剂量，可出院后自行隔离。大剂量1311治疗的患者,服药后48h的放射性辐射剂量较高。【中图分类号】R736.1【文献标识码】A【文章编号】2095-1752(2016)18-0062-02Studyonthesuitablehospitalizationlengthofdifferentiatedthyroid

3、cancerpatientsadministratedwith1311NiFaqiang.DepartmentofNuclearMedicine,ZhejiangCancerHospital,ZhejiangProvince,Hangzhou310022,China【Abstract】ObjectiveToresearchthepropertyhospitalizationlengthofdifferentiatedthyroidcancer(DTC)patientswhoadministratedwith131I.MethodsAtotalof58casesofDT

4、Cpatientswhoacceptedbilateralthyroidectomyasresearchedsubjects.Todividedpatientsbytheadministrated1311doseaslow-dosegroup(n=27,Dose=3700MBq)andhigh-dosegroup(n=31,Dose=7400MBq).Theradioactivedoseofallpatientsat48hand72hafter1311administrationweremeasuredatadistanceoflm,and400MBq131lasco

5、ntrolsource.ResultsTherewerestatisticallysignificant(t=2.311,p=0.028)oflowandhigh-dosegrouppatientsafteradministratedwith1311at48h.Theradioactivedosesoflowandhigh-dosegrouppatientswerelowerthancontrolsourceafter72h1311administration.Theradioactivedosesof17casespatients(low-dosegroup5cas

6、es,high-dosegroup12cases)werehigherthancontrolsource(n=27,Dose=3700MBq).ConclusionTheradioactivedoseofDTCpatientswhoacceptedl31ladministrationdecreasedobviouslyafter72handlowerthannationalcriterionof400Mbobviously.Thosepatientscoulddischargefromhospitalandperformself-isolation.However,t

7、hehigh-dosegrouppatientsstillhadhigherradioactivedoseafter48h.【Keywords】Differentiatedthyroidcancer;Radionuclidel31l;Hospitalization;Radioactivedose分化型甲状腺癌(Differentiatedthyroidcancer,DTC)是临床上常见的一种低度恶性的肿瘤，在我国其发病率已经上升至肿瘤发病率的第十位。临床上常行甲状腺肿物切除、甲状腺单叶切除、甲状腺全切除或次全切除等方法治疗［1-2］，不同的手术切除范